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RSK2 Polyclonal Antibody

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Antibody Testing Data (15)

RSK2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 15

RSK2 Antibody (23762-1-AP) in ICC/IF

Immunofluorescent analysis of HUVEC cells using 23762-1-AP (RSK2 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

RSK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

RSK2 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

RSK2 Antibody in Immunoprecipitation (IP)

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Product Details

23762-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:10-1:100

Immunocytochemistry (ICC/IF)

1:25

Immunoprecipitation (IP)

0.5-4.0 µg

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RSK2 Fusion Protein Ag20620 (666-740 aa encoded by BC096301)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QRLTAALVL RHPWIVHWDQ LPQYQLNRQD APHLVKGAMA ATYSALNRNQ SPVLEPVGRS TLAQRRGIKK ITSTAL (666-740 aa encoded by BC096301)

Target Information

RPS6KA3 (RSK2) is a serine/threonine kinase that modulates many cellular processes including transcription, adhesion, growth, survival, and proliferation. RPS6KA3 contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in the gene have been associated with Coffin-Lowry syndrome (CLS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.

PloS one

Pan J,Liu M,Duan X,Wang D

Mon Jun 12 00:00:00 EDT 2023

PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2.

International journal of molecular sciences

Chen Q,Jin J,Guo W,Tang Z,Luo Y,Ying Y,Lin H,Luo Z

Mon Aug 08 00:00:00 EDT 2022

β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.

Oncogene

Lu Y,Li X,Liu H,Xue J,Zeng Z,Dong X,Zhang T,Wu G,Yang K,Xu S

Mon Feb 01 00:00:00 EST 2021

FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM.

Cancers

Watanabe D,Nogami A,Okada K,Akiyama H,Umezawa Y,Miura O

Wed Nov 20 00:00:00 EST 2019

β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.

Cell death and differentiation

Ma J,Lu Y,Zhang S,Li Y,Huang J,Yin Z,Ren J,Huang K,Liu L,Yang K,Wu G,Xu S

Wed Aug 01 00:00:00 EDT 2018

β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer.

Cell death and differentiation

Ma J,Lu Y,Zhang S,Li Y,Huang J,Yin Z,Ren J,Huang K,Liu L,Yang K,Wu G,Xu S

Wed Aug 01 00:00:00 EDT 2018

MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components.

The Prostate

Su Z,Zhang M,Xu M,Li X,Tan J,Xu Y,Pan X,Chen N,Chen X,Zhou Q

Sun Apr 01 00:00:00 EDT 2018

MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components.

The Prostate

Su Z,Zhang M,Xu M,Li X,Tan J,Xu Y,Pan X,Chen N,Chen X,Zhou Q

Sun Apr 01 00:00:00 EDT 2018

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.

Theranostics

Huang Y,Hu K,Zhang S,Dong X,Yin Z,Meng R,Zhao Y,Dai X,Zhang T,Yang K,Liu L,Huang K,Shi S,Zhang Y,Chen J,Wu G,Xu S

Mon Jan 14 00:00:00 EST 2019

S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer.

Theranostics

Huang Y,Hu K,Zhang S,Dong X,Yin Z,Meng R,Zhao Y,Dai X,Zhang T,Yang K,Liu L,Huang K,Shi S,Zhang Y,Chen J,Wu G,Xu S

Mon Jan 14 00:00:00 EST 2019

DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.

The international journal of biochemistry & cell biology

Zhang Y,Gong FL,Lu ZN,Wang HY,Cheng YN,Liu ZP,Yu LG,Zhang HH,Guo XL

Fri Dec 01 00:00:00 EST 2017

DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.

The international journal of biochemistry & cell biology

Zhang Y,Gong FL,Lu ZN,Wang HY,Cheng YN,Liu ZP,Yu LG,Zhang HH,Guo XL

Fri Dec 01 00:00:00 EST 2017

Bioinformatics

Protein Aliases: 90 kDa ribosomal protein S6 kinase 3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; p90-RSK 3; pp90RSK2; ribosomal protein S6 kinase 2; Ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; Ribosomal S6 kinase 2; RSK-2; S6K-alpha-3

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Gene Aliases: C130006E23; CLS; HU-3; ISPK-1; ISPK1; MAPKAPK-1b; MAPKAPK1B; MPK-9; MRX19; p90-RSK2; p90RSK3; pp90RSK2; Rps6ka-rs1; RPS6KA3; RSK; RSK2; S6K-alpha3

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UniProt ID: (Human) P51812, (Mouse) P18654

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Entrez Gene ID: (Human) 6197, (Mouse) 110651

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Function(s)

magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity protein kinase binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process nucleotide binding ribosomal protein S6 kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein modifying enzyme

Process(es)

skeletal system development toll-like receptor signaling pathway protein phosphorylation apoptotic process cell cycle signal transduction central nervous system development positive regulation of cell growth response to lipopolysaccharide intracellular signal transduction negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of translation in response to stress regulation of DNA-templated transcription in response to stress positive regulation of cell differentiation positive regulation of transcription from RNA polymerase II promoter regulation of translation phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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RSK2 Polyclonal Antibody

RSK2 Antibody (23762-1-AP) in ICC/IF

Product Details

23762-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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