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Proteintech
RSK3 Polyclonal Antibody
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Product Details
14446-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RSK3 Fusion Protein Ag5862 (66-311 aa encoded by BC002363)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
37.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GQGSYGKVF LVRKVKGSDA GQLYAMKVLK KATLKVRDRV RSKMERDILA EVNHPFIVKL HYAFQTEGKL YLILDFLRGG DLFTRLSKEV MFTEEDVKFY LAELALALDH LHSLGIIYRD LKPENILLDE EGHIKITDFG LSKEAIDHDK RAYSFCGTIE YMAPEVVNRR GHTQSADWWS FGVLMFEMLT GSLPFQGKDR KETMALILKA KLGMPQFLSG EAQSLLRALF KRNPCNRLGA GIDGVEE (66-311 aa encoded by BC002363)
Target Information
RPS6KA2 (RSK3) serine/threonine kinase is a member of the ribosomal S6 kinase (RSK) family. It is believed that RPS6KA2 is a signal-transducing intermediate in the cellular response to several growth factors. It is found in many tissues, but in higher levels in lung and skeletal muscle. The p90 ribosomal S6 kinases (RSK)1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin-Lowry syndrome, which is characterized by mental retardation and growth deficits and may have a tonic regulation on G-protein coupled signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90RSK2; pp90RSK3; Protein-tyrosine kinase Mpk-9; ribosomal protein S6 kinase alpha 2; Ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kD, polypeptide 2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; Ribosomal S6 kinase 3; RSK-3; S6K-alpha 2; S6K-alpha-2; unnamed protein product
Gene Aliases: 90kDa; D17Wsu134e; HU-2; MAPKAPK1C; p90-RSK3; p90rsk; p90RSK2; pp90rsk; pp90RSK3; Rps6ka-rs1; RPS6KA2; RSK; RSK3; S6K-alpha; S6K-alpha2
UniProt ID: (Human) Q15349, (Mouse) Q9WUT3
Entrez Gene ID: (Human) 6196, (Mouse) 20112, (Rat) 117269
nucleotide binding
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
ribosomal protein S6 kinase activity
protein serine/threonine/tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
oocyte maturation
brain renin-angiotensin system
signal transduction
chemical synaptic transmission
heart development
negative regulation of cell proliferation
positive regulation of gene expression
cardiac muscle cell apoptotic process
intracellular signal transduction
TORC1 signaling
positive regulation of apoptotic process
negative regulation of cell cycle
negative regulation of meiotic nuclear division
heart contraction
regulation of protein processing
cellular response to carbohydrate stimulus
regulation of translation
protein phosphorylation
phosphorylation
peptidyl-serine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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