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Proteintech
RTKN Polyclonal Antibody
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Product Details
12762-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RTKN Fusion Protein Ag3265 (201-550 aa encoded by BC017727)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ATKLSSSLG RSSGRRVRAS LDSAGGSGSS PILLPTPVVG GPRYHLLAHT TLTLAAVQDG FRTHDLTLAS HEENPAWLPL YGSVCCRLAA QPLCMTQPTA SGTLRVQQAG EMQNWAQVHG VLKGTNLFCY RQPEDADTGE EPLLTIAVNK ETRVRAGELD QALGRPFTLS ISNQYGDDEV THTLQTESRE ALQSWMEALW QLFFDMSQWK QCCDEIMKIE TPAPRKPPQA LAKQGSLYHE MAIEPLDDIA AVTDILTQRE GARLETPPPW LAMFTDQPAL PNPCSPASVA PAPDWTHPLP WGRPRTFSLD AVPPDHSPRA RSVAPLPPQR SPRTRGLCSK GQPRTWLQSP V (201-550 aa encoded by BC017727)
Target Information
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: rho effector; Rhotekin; rtkn; rtkn {ECO:0000312|RGD:727874}
Gene Aliases: RTKN; RTKN-1; RTKN1
UniProt ID: (Human) Q9BST9, (Rat) Q6V7V2, (Mouse) Q8C6B2
Entrez Gene ID: (Human) 6242, (Rat) 297383, (Mouse) 20166
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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