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Proteintech
RTN4/NOGO Polyclonal Antibody
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Product Details
10950-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RTN4/NOGO Fusion Protein Ag1392 (1-373 aa encoded by BC012619)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEDLDQSPL VSSSDSPPRP QPAFKYQFVR EPEDEEEEEE EEEEDEDEDL EELEVLERKP AAGLSAAPVP TAPAAGAPLM DFGNDFVPPA PRGPLPAAPP VAPERQPSWD PSPVSSTVPA PSPLSAAAVS PSKLPEDDEP PARPPPPPPA SVSPQAEPVW TPPAPAPAAP PSTPAAPKRR GSSGSVVVDL LYWRDIKKTG VVFGASLFLL LSLTVFSIVS VTAYIALALL SVTISFRIYK GVIQAIQKSD EGHPFRAYLE SEVAISEELV QKYSNSALGH VNCTIKELRR LFLVDDLVDS LKFAVLMWVF TYVGALFNGL TLLILALISL FSVPVIYERH QAQIDHYLGL ANKNVKDAMA KIQAKIPGLK RKAE (1-373 aa encoded by BC012619)
Target Information
NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NSP; reticulon 5; Reticulon-4; Reticulon-5; RTN-x
Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI220/250; NOGO; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507
UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72
Entrez Gene ID: (Human) 57142, (Mouse) 68585
angiogenesis
nervous system development
axonogenesis
axonal fasciculation
negative regulation of neuron projection development
cerebral cortex radial glia guided migration
negative regulation of cell growth
regulation of cell migration
negative regulation of axon extension
positive regulation of dopamine secretion
negative regulation of neuron differentiation
positive regulation of glial cell differentiation
negative regulation of axonogenesis
regulation of sensory perception of pain
regulation of nervous system development
cardiac epithelial to mesenchymal transition
negative regulation of neuron projection regeneration
endoplasmic reticulum tubular network organization
regulation of branching morphogenesis of a nerve
apoptotic process
regulation of apoptotic process
nuclear pore complex assembly
endoplasmic reticulum tubular network assembly
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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