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Proteintech

RTN4/NOGO Polyclonal Antibody

9 References
View all (12) Nogo antibodies

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Product Details

10950-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

RTN4/NOGO Fusion Protein Ag1392 (1-373 aa encoded by BC012619)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Amount

25.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MEDLDQSPL VSSSDSPPRP QPAFKYQFVR EPEDEEEEEE EEEEDEDEDL EELEVLERKP AAGLSAAPVP TAPAAGAPLM DFGNDFVPPA PRGPLPAAPP VAPERQPSWD PSPVSSTVPA PSPLSAAAVS PSKLPEDDEP PARPPPPPPA SVSPQAEPVW TPPAPAPAAP PSTPAAPKRR GSSGSVVVDL LYWRDIKKTG VVFGASLFLL LSLTVFSIVS VTAYIALALL SVTISFRIYK GVIQAIQKSD EGHPFRAYLE SEVAISEELV QKYSNSALGH VNCTIKELRR LFLVDDLVDS LKFAVLMWVF TYVGALFNGL TLLILALISL FSVPVIYERH QAQIDHYLGL ANKNVKDAMA KIQAKIPGLK RKAE (1-373 aa encoded by BC012619)

Target Information

Nogo, also known as RTN4, encodes a membrane protein that limits axon growth and regeneration in the central nervous system. The gene produces multiple isoforms (Nogo-A, Nogo-B, Nogo-C) via alternative promoters and splicing; Nogo-A is highly expressed in oligodendrocytes and is the principal inhibitor of neurite outgrowth. Nogo engages receptors including NgR1 (RTN4R), LINGO1, and p75 or TROY, activating RhoA/ROCK signaling that stabilizes growth cone collapse and restricts plasticity after injury. Beyond axon guidance, Nogo isoforms contribute to membrane dynamics, endoplasmic reticulum structure, vascular function, and immune signaling. Experimental blockade of Nogo or its receptor complex can enhance sprouting and functional recovery in animal models, making the pathway a target for therapies in spinal cord injury and stroke.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ASY; Foocen; Human NogoA; My043 protein; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; Nogo protein; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RTN4-C; NSP; reticulon; Reticulon 4; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; Rtn4; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4a; RTN4b; RTN4c; unnamed protein product

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Gene Aliases: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; KIAA0886; mKIAA0886; mKIAA4153; My043; Nbla00271; Nbla10545; NgA; NI220/250; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP; NSP-CL; RTN-X; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; SP1507

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UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72

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Entrez Gene ID: (Human) 57142, (Mouse) 68585

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Function(s)
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding protein complex binding poly(A) RNA binding
Process(es)
angiogenesis nervous system development axonogenesis axonal fasciculation negative regulation of neuron projection development cerebral cortex radial glia guided migration negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of dopamine secretion negative regulation of neuron differentiation positive regulation of glial cell differentiation negative regulation of axonogenesis regulation of sensory perception of pain regulation of nervous system development cardiac epithelial to mesenchymal transition negative regulation of neuron projection regeneration endoplasmic reticulum tubular network organization regulation of branching morphogenesis of a nerve blastocyst formation leukocyte migration involved in inflammatory response apoptotic process endoplasmic reticulum organization brain development positive regulation of epithelial cell migration central nervous system vasculogenesis neuron differentiation positive regulation of mammary gland epithelial cell proliferation positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis regulation of apoptotic process positive regulation of angiogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling positive regulation of macrophage cytokine production protein localization to lysosome cellular response to hypoxia endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis endoplasmic reticulum tubular network membrane organization positive regulation of hepatocyte proliferation negative regulation of vasculogenesis
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