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Invitrogen

RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (12F7)

View all (7) RUNX1/RUNX2/RUNX3 antibodies

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Product Details

MA573505

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

12F7

Immunogen

KLH conjugated synthetic peptide derived from human RUNX.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.125 mg/mL

Amount

12.5 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are welldocumented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acute myeloid leukemia 1 protein; acute myeloid leukemia 2 protein; acute myeloid leukemia 3 protein; acute myeloid leukemia gene 2; AKV core binding factor; AML1; AML1-ETO fusion; AML1-ETO fusion protein; AML1-EVI-1 fusion protein; CBF-alpha-3; CBFA2; core binding factor alpha 1; core binding factor alpha 2; core binding factor alpha 3; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); core-binding factor subunit alpha-1; core-binding factor subunit alpha-2; core-binding factor subunit alpha-3; core-binding factor, runt domain, alpha subunit 1; core-binding factor, runt domain, alpha subunit 2; core-binding factor, runt domain, alpha subunit 3; mutant RUNX1; nuclear protein; oncogene AML-1; oncogene AML-2; oncogene AML-3; osteoblast-specific transcription factor 2; PEA2 alpha C; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha A; PEBP2 alpha C; PEBP2-alpha A; PEBP2-alpha B; PEBP2-alpha C; polyomavirus enhancer-binding protein 2 alpha A subunit; polyomavirus enhancer-binding protein 2 alpha B subunit; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt domain, alpha subunit 3; runt related transcription factor 1; runt related transcription factor 2; Runt related transcription factor 3; RUNX 2; RUNX-2; RUNX1 with skipped exon 5; similar to Homo sapiens AML1c; acute myeloid leukemia 1; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor; transcription factor AML2; transcription factor AML2/CBFA3; transcription factor Cbfa1/Osf2; unnamed protein product

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Gene Aliases: AML1; AML1-EVI-1; AML2; AML3; AMLCR1; Cbf; CBF-alpha-1; CBF-alpha-2; CBF2alpha; Cbfa-1; CBFA1; CBFA2; CBFA3; CCD; CCD1; CLCD; EVI-1; LS3; OSF-2; OSF2; PEA2-alpha; PEA2aA; PEBP2-alpha; Pebp2a1; Pebp2a2; Pebp2a3; PEBP2aA; PEBP2aB; PEBP2aC; PEBP2alpha; Pebpa2a; Pebpa2b; Rx3

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UniProt ID: (Human) Q01196, (Human) Q13950, (Human) Q13761, (Rat) Q63046, (Mouse) Q08775, (Mouse) Q64131

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Entrez Gene ID: (Human) 861, (Human) 860, (Human) 864, (Mouse) 12394, (Rat) 50662, (Mouse) 12393, (Rat) 367218, (Rat) 156726, (Mouse) 12399

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding protein binding ATP binding protein homodimerization activity protein heterodimerization activity DNA-binding transcription factor binding sequence-specific double-stranded DNA binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding promoter-specific chromatin binding core promoter proximal region sequence-specific DNA binding chromatin binding protein domain specific binding chromatin DNA binding histone deacetylase binding bHLH transcription factor binding general transcription initiation factor binding SMAD binding
Process(es)
skeletal system development ossification osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway cell proliferation positive regulation of cell proliferation gene expression regulation of gene expression positive regulation of Schwann cell proliferation positive regulation of gene expression hemopoiesis neuron differentiation T cell differentiation regulation of ossification BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis ligamentous ossification regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth regulation of cell differentiation regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cell development cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation positive regulation of multicellular organismal process SMAD protein signal transduction response to sodium phosphate regulation of multicellular organismal development negative regulation of transcription from RNA polymerase II promoter myeloid leukocyte differentiation regulation of plasminogen activation myeloid cell differentiation negative regulation of granulocyte differentiation positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of collagen biosynthetic process negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation positive regulation of angiogenesis peripheral nervous system neuron development positive regulation of developmental process regulation of cardiac muscle cell proliferation cardiac muscle tissue regeneration hematopoietic stem cell proliferation positive regulation of extracellular matrix organization regulation of connective tissue replacement protein phosphorylation axon guidance biological_process hair follicle morphogenesis neuron projection development negative regulation of cell cycle negative regulation of epithelial cell proliferation response to transforming growth factor beta positive regulation of extrinsic apoptotic signaling pathway in utero embryonic development liver development myeloid progenitor cell differentiation regulation of T cell anergy central nervous system development negative regulation of cell proliferation regulation of signal transduction response to retinoic acid positive regulation of interferon-gamma production embryonic hemopoiesis behavioral response to pain neuron fate commitment neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion response to denervation involved in regulation of muscle adaptation response to mechanical stimulus response to insulin cellular response to zinc ion starvation cellular response to fibroblast growth factor stimulus cellular response to calcium ion cellular response to parathyroid hormone stimulus cellular response to hyperoxia response to dexamethasone dentinogenesis bone regeneration
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