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RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (6G5U2)

View all (7) RUNX1/RUNX2/RUNX3 antibodies

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RUNX1/RUNX2/RUNX3 Recombinant Rabbit Monoclonal Antibody (6G5U2)

Product Details

MA5-35649

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6G5U2

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 354-453 of human RUNX1/2/3 (NP_0010018901)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Amount

28 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849549

Product Specific Information

Immunogen sequence: LPPPYPGSSQ AQGGPFQASS PSYHLYYGAS AGSYQFSMVG GERSPPRILP PCTNASTGSA LLNPSLPNQS DVVEAEGSHS NSPTNMAPSA RLEEAVWRPY

Target Information

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are welldocumented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; Acute myeloid leukemia 2 protein; Acute myeloid leukemia 3 protein; AKV core binding factor; CBF-alpha-1; CBF-alpha-2; CBF-alpha-3; core binding factor alpha 1; core binding factor alpha 2; core binding factor alpha 3; Core-binding factor subunit alpha-1; Core-binding factor subunit alpha-2; Core-binding factor subunit alpha-3; Oncogene AML-1; Oncogene AML-2; Oncogene AML-3; OSF-2; Osteoblast-specific transcription factor 2; PEA2-alpha A; PEA2-alpha B; PEA2-alpha C; PEBP2 alpha A; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha A subunit; Polyomavirus enhancer-binding protein 2 alpha B subunit; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 1; runt domain, alpha subunit 2; runt domain, alpha subunit 3; Runt-related transcription factor 1; Runt-related transcription factor 2; Runt-related transcription factor 3; RUNX 2; RUNX-2; SL3-3 enhancer factor 1 alpha A subunit; SL3-3 enhancer factor 1 alpha B subunit; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha A subunit; SL3/AKV core-binding factor alpha B subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3

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Gene Aliases: AML1; AML2; AML3; Cbf; CBF-alpha-2; Cbfa-1; CBFA1; CBFA2; CBFA3; LS3; OSF2; PEBP2A; Pebp2a1; Pebp2a2; PEBP2A3; PEBP2aA; Pebpa2a; Pebpa2b; RUNX1; RUNX2; RUNX3

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UniProt ID: (Mouse) Q08775, (Mouse) Q64131

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Entrez Gene ID: (Mouse) 12394, (Mouse) 12393, (Mouse) 12399

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Function(s)
regulatory region DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding protein binding ATP binding transcription factor binding protein homodimerization activity protein heterodimerization activity repressing transcription factor binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding protein domain specific binding histone deacetylase binding bHLH transcription factor binding transcription regulatory region DNA binding Runt transcription factor
Process(es)
skeletal system development in utero embryonic development liver development myeloid progenitor cell differentiation regulation of T cell anergy transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter central nervous system development negative regulation of cell proliferation regulation of signal transduction hemopoiesis myeloid cell differentiation neuron differentiation negative regulation of granulocyte differentiation positive regulation of granulocyte differentiation hair follicle morphogenesis response to retinoic acid positive regulation of interferon-gamma production positive regulation of interleukin-2 production embryonic hemopoiesis positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion osteoblast differentiation endochondral ossification osteoblast fate commitment chondrocyte differentiation chondrocyte development osteoblast development positive regulation of cell proliferation positive regulation of gene expression T cell differentiation regulation of ossification BMP signaling pathway positive regulation of chondrocyte differentiation embryonic forelimb morphogenesis regulation of fibroblast growth factor receptor signaling pathway odontogenesis of dentin-containing tooth regulation of odontogenesis of dentin-containing tooth regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of smoothened signaling pathway cell maturation embryonic cranial skeleton morphogenesis skeletal system morphogenesis stem cell differentiation cellular response to BMP stimulus positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus negative regulation of transcription from RNA polymerase II promoter ossification protein phosphorylation axon guidance neuron projection development interferon-gamma production mRNA transcription from RNA polymerase II promoter regulation of cell differentiation negative regulation of cell cycle negative regulation of epithelial cell proliferation positive regulation of extrinsic apoptotic signaling pathway
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