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Invitrogen
RXFP2 Polyclonal Antibody
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FIGURE: 1 / 1
RXFP2 Antibody (PA5-89738) in WB
Western blot analysis of RXFP2 in extracts of various cell lines. Samples were incubated with RXFP2 Polyclonal antibody (Product # PA5-89738) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-89738
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 80-180 of human RXFP2 (NP_5707181)
Conjugate
Form
Liquid
Concentration
1.44 mg/mL
Amount
144 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: CGDTSGWATI FGTVHGNANS VALTQECFLK QYPQCCDCKE TELECVNGDL KSVPMISNNV TLLSLKKNKI HSLPDKVFIK YTKLKKIFLQ HNCIRHISRK A; Positive Samples: Mouse kidney, Rat kidney; Cellular Location: Cell membrane, Multi-pass membrane protein
Target Information
The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum and in brain. Not detected in kidney, spleen and heart.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: G protein coupled receptor affecting testicular descent; G protein-coupled receptor 106; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; INSL3 receptor; leucine-rich repeat-containing G protein-coupled receptor 8; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2; Relaxin receptor 2
Gene Aliases: Gpcr; Gpr106; Great; Lgr8; Rxfp2
UniProt ID: (Mouse) Q91ZZ5
Entrez Gene ID: (Mouse) 140498, (Rat) 363866
oocyte maturation
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of cell proliferation
male gonad development
positive regulation of cAMP biosynthetic process
negative regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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