Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 6 publications 6 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
RXRA Fusion Protein Ag15651 (113-462 aa encoded by BC110998) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
This antibody is a rabbit polyclonal antibody raised against the 350 AA of human RXRA C-terminal. RXRA is highly expressed in liver, also expressed in lung, kidney and heart. It specifically recognizes the 51 kDa human RXRA protein.
Immunogen sequence: LNGVLKVPA HPSGNMASFT KHICAICGDR SSGKHYGVYS CEGCKGFFKR TVRKDLTYTC RDNKDCLIDK RQRNRCQYCR YQKCLAMGMK REAVQEERQR GKDRNENEVE STSSANEDMP VERILEAELA VEPKTETYVE ANMGLNPSSP NDPVTNICQA ADKQLFTLVE WAKRIPHFSE LPLDDQVILL RAGWNELLIA SFSHRSIAVK DGILLATGLH VHRNSAHSAG VGAIFDRVLT ELVSKMRDMQ MDKTELGCLR AIVLFNPDSK GLSNPAEVEA LREKVYASLE AYCKHKYPEQ PGRFAKLLLR LPALRSIGLK CLEHLFFFKL IGDTPIDTFL MEMLEAPHQM T (113-462 aa encoded by BC110998)
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha; RXR alpha 1
Gene Aliases: 9530071D11Rik; NR2B1; RXRA; RXRalpha1
UniProt ID: (Human) P19793, (Mouse) P28700
Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181
Molecular Function:
C4 zinc finger nuclear receptor
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