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Proteintech
RXRG Polyclonal Antibody
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Product Details
11129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RXRG Fusion Protein Ag1611 (164-463 aa encoded by BC012063)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRTIRKDLI YTCRDNKDCL IDKRQRNRCQ YCRYQKCLVM GMKREAVQEE RQRSRERAES EAECATSGHE DMPVERILEA ELAVEPKTES YGDMNMENST NDPVTNICHA ADKQLFTLVE WAKRIPHFSD LTLEDQVILL RAGWNELLIA SFSHRSVSVQ DGILLATGLH VHRSSAHSAG VGSIFDRVLT ELVSKMKDMQ MDKSELGCLR AIVLFNPDAK GLSNPSEVET LREKVYATLE AYTKQKYPEQ PGRFAKLLLR LPALRSIGLK CLEHLFFFKL IGDTPIDTFL MEMLETPLQI T (164-463 aa encoded by BC012063)
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 3; Retinoic acid receptor RXR-gamma; retinoic X receptor gamma-1; retinoid X receptor; Retinoid X receptor gamma; retinoid X receptor, gamma; RXR gamma; RXR gamma-1
Gene Aliases: NR2B3; RXRC; RXRG
UniProt ID: (Human) P48443, (Rat) Q5BJR8, (Mouse) P28705
Entrez Gene ID: (Human) 6258, (Rat) 83574, (Mouse) 20183
RNA polymerase II regulatory region sequence-specific DNA binding
steroid hormone receptor activity
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
transcription initiation from RNA polymerase II promoter
steroid hormone mediated signaling pathway
retinoic acid receptor signaling pathway
protein homotetramerization
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
transcription, DNA-templated
transcription from RNA polymerase II promoter
peripheral nervous system development
heart development
skeletal muscle tissue development
response to organic cyclic compound
neuron differentiation
regulation of myelination
response to retinoic acid
cellular response to hormone stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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