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Immunogen sequence: DDSISASSS SQGLSQPSTQ TTQYLRADTP NNATPITSSL GYPTLRIEKN DLRSVTLLEA KGKVKDIAIS RERITLKDVL QEGTFGRIFH GILIDEKDPN KEKQAFVKTV KDQASEIQVT MMLTESCKLR GLHHRNLLPI THVCIEEGEK PMVILPYMNW GNLKLFLRQC KLVEANNPQA ISQQDLVHMA IQIACGMSYL ARREVIHKDL AARNCVIDDT LQVKITDNAL SRDLFPMDYH CLGDNENRPV RWMALESLVN NEFSSASDVW AFGVTLWELM TLGQTPYVDI DPFEMAAYLK DGYRIAQPIN CPDELFAVMA CCWALDPEER PKFQQLVQCL TEFHAALGAY V (261-610 aa encoded by BC153090)
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
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Protein Aliases: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
Molecular Function: transmembrane signal receptor