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Product Details
22138-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
RYK Fusion Protein Ag17540 (261-610 aa encoded by BC153090)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DDSISASSS SQGLSQPSTQ TTQYLRADTP NNATPITSSL GYPTLRIEKN DLRSVTLLEA KGKVKDIAIS RERITLKDVL QEGTFGRIFH GILIDEKDPN KEKQAFVKTV KDQASEIQVT MMLTESCKLR GLHHRNLLPI THVCIEEGEK PMVILPYMNW GNLKLFLRQC KLVEANNPQA ISQQDLVHMA IQIACGMSYL ARREVIHKDL AARNCVIDDT LQVKITDNAL SRDLFPMDYH CLGDNENRPV RWMALESLVN NEFSSASDVW AFGVTLWELM TLGQTPYVDI DPFEMAAYLK DGYRIAQPIN CPDELFAVMA CCWALDPEER PKFQQLVQCL TEFHAALGAY V (261-610 aa encoded by BC153090)
Target Information
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
frizzled binding
protein binding
ATP binding
Wnt-protein binding
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
protein phosphorylation
signal transduction
axonogenesis
axon guidance
synapse assembly
Wnt signaling pathway
peptidyl-tyrosine phosphorylation
neurogenesis
corpus callosum development
neuron differentiation
neuron projection development
cell proliferation in midbrain
non-canonical Wnt signaling pathway
chemorepulsion of dopaminergic neuron axon
positive regulation of MAPK cascade
canonical Wnt signaling pathway
commissural neuron axon guidance
planar cell polarity pathway involved in axon guidance
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
skeletal system morphogenesis
negative regulation of axon extension involved in axon guidance
negative chemotaxis
phosphorylation
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