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RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
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Protein Aliases: growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK; Tyrosine-protein kinase RYK precursor
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
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