Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:1,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:100 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
KLH conjugated synthetic peptide between 160-190 amino acids from human RYK |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.3 mg/mL |
Purification |
Antigen affinity chromatography, Protein A |
Storage buffer |
PBS |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2285487 |
RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ERK3; growth factor receptor; hydroxyaryl-protein kinase; JTK5A protein tyrosine kinase; Kinase VIK; Met-related kinase; NYK-R; Tyrosine-protein kinase RYK
Gene Aliases: AW536699; D3S3195; ERK-3; JTK5; JTK5A; Mrk; RYK; RYK1; Vik
UniProt ID: (Human) P34925, (Mouse) Q01887
Entrez Gene ID: (Human) 6259, (Rat) 140585, (Mouse) 20187
Molecular Function:
transmembrane signal receptor
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