A suggested positive control is rat brain tissue lysate.
PA5-21117 can be used with blocking peptide PEP-1231.
RABEX5 is a guanine nucleotide exchange factor (GEF) that forms a complex with rabaptin-5 and specifically activates Rab5, a small GTPase that plays an essential role in endocytic traffic. RABEX-5 is thought to also interact with another member of the Rab family, Rab22, which targets RABEX5 to early endosomes, allowing it to activate Rab5 and thereby promote Rab5-mediated endosome fusion.
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Protein Aliases: RAB guanine nucleotide exchange factor (GEF) 1; Rab5 exchange factor; Rab5 GDP/GTP exchange factor; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RABEX5, rabex-5; RAP1; Ras negative regulator Rabex-5; Ras negative regulator Rabex-5/Rin2
Gene Aliases: Rab5ef; rabex-5; RABEX5; RABGEF1; RAP1; Rin2