Immunogen sequence: SKGYSTWLKL NKKVTQQDVK KENPLQFKFR AKFFPEDVSE ELIQEITQRL FFLQVKEAIL NDEIYCPPET AVLLASYAVQ AKYGDYNKEI HKPGYLANDR LLPQRVLEQH KLTKEQWEER IQ
RAC, a small GTPase in the ras family, regulates the formation of membrane ruffles, lamellipodia and filopodia. It is involved in cytoskeletal actin organization and transformation. The p21 activated kinases (PAKs) are direct targets of active Rac and Cdc42 which can induce the assembly of polarized cytoskeletal structures when expressed in fibroblasts. RAC1 and RAC2 are also essential components of NADPH oxidase, the enzyme responsible for generating free radicals.
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Protein Aliases: DFNB24; ESP10; Radixin; radixin isoform
Gene Aliases: AA516625; DFNB24; RDX