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AbboMax
RalA Polyclonal Antibody
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FIGURE: 1 / 1
RalA Antibody (620-780) in IHC (P)
Immunohistochemistry: Human breast carcinoma (FFPE) stained with Rabbit anti-RalA (paired S196) (Cat# 620-780) at 1:200 for 10 min @ RT. Staining of formalin-fixed tissue requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Product Details
620-780
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KKR KSL AKR IRE R
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: Breast carcinoma
Cellular location: Cell membrane.
Target Information
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: -ral simian leukemia viral oncogene homolog A (ras related); GTP-binding protein (ral); MGC48949; ral-A protein; RALA Ras like proto-oncogene A; Ras family small GTP binding protein RALA; ras related GTP binding protein A; RAS-like protein A; RAS-like, family 1; Ras-related protein Ral-A; small GTP binding protein; unnamed protein product; v-ral simian leukemia viral oncogene homolog A (ras related)
Gene Aliases: 3010001O15Rik; AW322615; HINCONS; RAL; Ral-a; RALA; Rasl1
UniProt ID: (Human) P11233, (Mouse) P63321, (Rat) P63322
Entrez Gene ID: (Human) 5898, (Mouse) 56044, (Rat) 81757
neural tube closure
exocytosis
chemotaxis
signal transduction
Ras protein signal transduction
regulation of exocytosis
receptor internalization
regulation of actin cytoskeleton organization
positive regulation of epidermal growth factor receptor signaling pathway
cell division
positive regulation of filopodium assembly
membrane raft localization
establishment of protein localization to mitochondrion
positive regulation of mitochondrial fission
regulation of postsynaptic neurotransmitter receptor internalization
cytokinesis
cell cycle
small GTPase mediated signal transduction
actin cytoskeleton reorganization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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