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Proteintech
RbAp46 Polyclonal Antibody
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Product Details
20365-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to RBBP7.
Target Information
This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: G1/S transition control protein-binding protein; G1/S transition control protein-binding protein RbAp46; Histone acetyltransferase type B subunit 2; Histone-binding protein RBBP7; Nucleosome-remodeling factor subunit RBAP46; RBBP-7; RBBP7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46; retinoblastoma-binding protein RbAp46; unnamed protein product
Gene Aliases: AA409861; AI173248; AU019541; BB114024; mRbAp46; RBAP46; RBBP7; SPGFX9
UniProt ID: (Human) Q16576, (Mouse) Q60973, (Rat) Q71UF4
Entrez Gene ID: (Human) 5931, (Mouse) 245688, (Rat) 83712
negative regulation of transcription from RNA polymerase II promoter
DNA replication
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
negative regulation of cell growth
negative regulation of transcription, DNA-templated
cellular heat acclimation
chromatin organization
brain development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
regulation of cell fate specification
positive regulation of transcription, DNA-templated
response to steroid hormone
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
regulation of stem cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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