Invitrogen

Reelin Polyclonal Antibody

1 Reference
View all (13) Reelin antibodies

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Datasheet
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Reelin Polyclonal Antibody

Product Details

PA5-78413

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Published species

C. elegans

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of mouse Reelin. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.69 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736514

Product Specific Information

Positive Control: mouse brain, rat brain

Predicted Reactivity: Human (97%), Chicken (91%), Sheep (98%), Bovine (97%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: extracellular matrix serine protease; Reeler protein; Reelin

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Gene Aliases: Reelen; reeler; Reln; Rl

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UniProt ID: (Mouse) Q60841, (Rat) Q80T65

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Entrez Gene ID: (Mouse) 19699, (Rat) 24718

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Function(s)
protein binding peptidase activity serine-type peptidase activity hydrolase activity metal ion binding lipoprotein particle receptor binding very-low-density lipoprotein particle receptor binding molecular_function protein serine/threonine/tyrosine kinase activity cell adhesion molecule extracellular matrix glycoprotein extracellular matrix protein
Process(es)
cell morphogenesis involved in differentiation neuron migration proteolysis cell adhesion multicellular organism development axon guidance central nervous system development brain development long-term memory locomotory behavior associative learning glial cell differentiation regulation of gene expression positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling dendrite development cell migration peptidyl-tyrosine phosphorylation spinal cord patterning dentate gyrus development hippocampus development cerebral cortex tangential migration layer formation in cerebral cortex cerebral cortex development forebrain development positive regulation of TOR signaling positive regulation of CREB transcription factor activity protein localization to synapse reelin-mediated signaling pathway thyroid hormone metabolic process positive regulation of protein kinase activity response to pain positive regulation of peptidyl-tyrosine phosphorylation regulation of behavior modulation of synaptic transmission positive regulation of small GTPase mediated signal transduction positive regulation of synaptic transmission, glutamatergic positive regulation of dendritic spine morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of synapse maturation postsynaptic density assembly NMDA glutamate receptor clustering postsynaptic density protein 95 clustering receptor localization to synapse lateral motor column neuron migration positive regulation of long-term synaptic potentiation positive regulation of lateral motor column neuron migration regulation of N-methyl-D-aspartate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity midgut development memory response to mechanical stimulus response to toxic substance response to hormone response to lithium ion response to organic cyclic compound response to insecticide ventral spinal cord development orbitofrontal cortex development hypothalamus development response to progesterone social behavior response to drug response to amino acid response to ethanol response to axon injury response to corticosterone response to electrical stimulus response to fatty acid cellular response to dexamethasone stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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