Positive Control: mouse brain, rat brain
Predicted Reactivity: Human (97%), Chicken (91%), Sheep (98%), Bovine (97%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: extracellular matrix serine protease; reeler; Reeler protein; Reelin; Reln; rl
Gene Aliases: Reelen; reeler; Reln; Rl