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Invitrogen
Reelin Polyclonal Antibody
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Product Details
PA5149714
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human RELN
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: QYSNDNGILW HLLRELDFMS FLEPQIISID LPQDAKTPAT AFRWWQPQHG KHSAQWALDD VLIGMNDSSQ TGFQDKFDGS IDLQANWYRI QGGQVDIDCL
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
Target Information
Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Reelin; unnamed protein product
Gene Aliases: ETL7; LIS2; PRO1598; RELN; RL
UniProt ID: (Human) P78509
Entrez Gene ID: (Human) 5649
cell morphogenesis
neuron migration
proteolysis
cell adhesion
axon guidance
central nervous system development
brain development
learning
long-term memory
locomotory behavior
associative learning
glial cell differentiation
regulation of gene expression
positive regulation of neuron projection development
dendrite development
cell migration
spinal cord patterning
ventral spinal cord development
hippocampus development
cerebral cortex tangential migration
layer formation in cerebral cortex
cerebral cortex development
forebrain development
positive regulation of TOR signaling
protein localization to synapse
reelin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of neuron differentiation
response to pain
regulation of behavior
modulation of synaptic transmission
positive regulation of small GTPase mediated signal transduction
positive regulation of protein kinase B signaling
positive regulation of synaptic transmission, glutamatergic
regulation of synaptic activity
long-term synaptic potentiation
positive regulation of dendritic spine morphogenesis
regulation of synapse maturation
positive regulation of synapse maturation
postsynaptic density assembly
NMDA glutamate receptor clustering
postsynaptic density protein 95 clustering
receptor localization to synapse
motor neuron migration
lateral motor column neuron migration
positive regulation of long-term synaptic potentiation
positive regulation of lateral motor column neuron migration
interneuron migration
positive regulation of excitatory postsynaptic potential
regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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