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Proteintech
Reticulocalbin 3 Polyclonal Antibody
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Product Details
27497-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Reticulocalbin 3 Fusion Protein Ag26569 (71-161 aa encoded by BC013436)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LTPEESQAR LGRIVDRMDR AGDGDGWVSL AELRAWIAHT QQRHIRDSVS AAWDTYDTDR DGRVGWEELR NATYGHYAPG EEFHDVEDAE TY (71-161 aa encoded by BC013436)
Target Information
Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EF-hand calcium-binding protein RLP49; HRP-iso; reticulocabin; reticulocalbin 3, EF-hand calcium binding domain; Reticulocalbin-3
Gene Aliases: RCN3; RLP49; UNQ239/PRO272
UniProt ID: (Human) Q96D15
Entrez Gene ID: (Human) 57333
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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