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Invitrogen
RhoBTB1/RhoBTB2 Polyclonal Antibody
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Product Details
PA5-104502
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RHBT2, corresponding to a region within C-terminal amino acids.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RHBT2.
Target Information
RHOBTB1 (Rho-related BTB domain-containing protein 1) and RHOBTB3 (Rho-related BTB domain-containing protein 3) each contain two BTB (POZ) domains and belong to the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. While both RHOBTB1 and RHOBTB3 are expressed ubiquitously, RHOBTB1 is found at high levels in placenta, stomach, testis, kidney and skeletal muscle, whereas RHOBTB3 is found at high levels in neural and cardiac tissues. RHOBTB1 is thought to play a role in GTPase-mediated signaling and may participate in organization of the Actin filament system. Additionally, RHOBTB1 expression is decreased in head and neck carcinomas, suggesting a possible role for RHOBTB1 as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deleted in breast cancer 2 gene protein; Deleted in breast cancer 2 gene protein homolog; p83; Rho-related BTB domain-containing protein 1; Rho-related BTB domain-containing protein 2; unnamed protein product
Gene Aliases: 1700008H16Rik; 3110048G13Rik; AI173445; AI573858; AV350930; DBC2; DEE64; E130206H14Rik; EIEE64; KIAA0717; KIAA0740; mKIAA0717; p83; RHOBTB1; RHOBTB2
UniProt ID: (Human) O94844, (Human) Q9BYZ6, (Mouse) Q9DAK3, (Mouse) Q91V93
Entrez Gene ID: (Human) 9886, (Human) 23221, (Mouse) 69288, (Mouse) 246710
actin filament organization
establishment or maintenance of cell polarity
signal transduction
small GTPase mediated signal transduction
regulation of cell shape
cortical cytoskeleton organization
regulation of actin cytoskeleton organization
ubiquitin-dependent protein catabolic process
protein ubiquitination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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