Immunogen sequence: VLKYDDFLKS TQKSPATAPK PMPPRPPLPN QQFGVSLQHL QEKNPEQEPI PIVLRETVAY LQAHALTTEG IFRRSANTQV VREVQQKYNM GLPVDFDQYN ELHLPAVILK TFLRELPEPL LTFDLYPHVV GFLNIDESQR VPATLQVLQT LPEENYQVLR FLTAFLVQIS AHSDQNKMTN TNLAVVFGPN LLWAKDAAIT LKAINPINTF TKFLLDHQGE LFPSPDPSGL; Positive Samples: BxPC-3, HeLa, HepG2, U-87MG, PC-12, Mouse lung; Cellular Location: Cytoplasm
The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase - activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.
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Protein Aliases: CDC42 GTPase-activating protein; GTPase-activating protein rhoGAP; GTPase-activating protein rhoOGAP; GTPase-activating protein, Rho, 1; p50-RhoGAP; Rho GTPase-activating protein 1; Rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1
Gene Aliases: ARHGAP1; B230365D05Rik; C76222; CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1