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Invitrogen
RhoH Polyclonal Antibody
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Product Details
PA5-92920
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.32 mg/mL
Amount
132 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: BT-474, SW620, Jurkat, HT-29, Mouse spleen, Mouse thymus, Mouse liver; Cellular Location: Cell membrane, Cytoplasm, Cytoplasmic side, Lipid-anchor
Target Information
The Rho subfamily of small GTP-binding proteins mediates many fundamental cellular functions. The commonly studied members (Rho, Rac, and CDC42) regulate actin reorganization and affect diverse cellular responses, including adhesion, cytokinesis, and motility. RhoH, also known as TTF (Translocation Three Four), Rho-related GTP-binding protein and ras homolog gene family member H, is unlike most other small G proteins. Most small G proteins are expressed ubiquitously, however, Rho H is expressed only in hemopoietic cells and tissues. Translocations and a high frequency of Rho H mutation have been detected in primary lymphoma cells. Rho H expression has also been observed in activated neutrophils. RhoH is GTPase deficient, remaining in a GTP-bound activated state without cycling. Rho H may be involved in the functional differentiation of T cells and in cytoskeleton organization. The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191 -amino acid polypeptide.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARHH; GTP-binding protein TTF; ras homolog gene family, member H; Rho-related GTP-binding protein RhoH; small GTP binding protein; Translocation three four protein; TTF, translocation three four; unnamed protein product
Gene Aliases: 5830400A04Rik; ARHH; AU019774; IMD129; RHOH; TTF
UniProt ID: (Human) Q15669, (Mouse) Q9D3G9
Entrez Gene ID: (Human) 399, (Mouse) 74734
regulation of transcription, DNA-templated
actin filament organization
signal transduction
small GTPase mediated signal transduction
T cell differentiation
negative regulation of I-kappaB kinase/NF-kappaB signaling
mast cell activation
positive regulation of T cell differentiation
negative regulation of phosphorylation
negative regulation of catalytic activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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