Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
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Specificity: The antibody binds to the C-terminus of rhodopsin on the cytoplasmic side of disk membranes. The epitope has the following amino acid sequence: 'TETSQVAPA'. A limitation of the 1D4 tag, however, is that it has to be placed at the C-terminus of a protein. This is because the Rho1D4 monoclonal antibody requires a free carboxylate group for high affinity binding. Amidation of the carboxyl group lowers its immunoreactivity to the Rho1D4 antibody by over 100 fold.
Visual pigments such as rhodopsin and porphyropsin are light-absorbing molecules that mediate vision. Rhodopsin consists of an apoprotein, opsin, covalently linked to 11-cis-retinal. This receptor is coupled to the activation of phospholipase C. Porphyropsin consists of opsin covalently linked to 11-cis 3,4-didehydroretinal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: L opsin; Long Wavelength Sensitive opsin; LWS opsin; MGC138309; MGC138311; OPN 2; opsin 2; opsin 2, rod pigment; Opsin-2; Red Opsin; retinal rod opsin pigment rh1.1; Rhodopsin; rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant); Rhodopsin (retinitis pigmentosa 4, autosomal dominant); rhodopsin-like-1.1 rod opsin; Rod Opsin; RP 4; seven transmembrane light receptor
Gene Aliases: CSNBAD1; Noerg1; OPN2; Ops; Rh; RH1; rh1.1; RHO; RP4; wu:fi06d11; zfo2; zfrho
UniProt ID: (Bovine) P02699, (Human) P08100, (Rat) P51489, (Mouse) P15409, (Zebrafish) P35359
Entrez Gene ID: (Bovine) 509933, (Human) 6010, (Rat) 24717, (Mouse) 212541, (Zebrafish) 30295
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