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Runx3 Polyclonal Antibody
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Product Details
OSR00270W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the internal region of rat Runx3 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen is homologous in mouse.
Specificity of this antibody: Runx3.
Target Information
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acute myeloid leukemia 2 protein; CBF-alpha 3; CBF-alpha-3; core binding factor alpha 3; Core-binding factor subunit alpha-3; Oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; Polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; Runt related transcription factor 3; Runt-related transcription factor 3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3
Gene Aliases: AML2; Cbfa3; Pebp2a3; Runx3
UniProt ID: (Mouse) Q64131
Entrez Gene ID: (Mouse) 12399, (Rat) 156726
negative regulation of transcription from RNA polymerase II promoter
ossification
chondrocyte differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
axon guidance
hemopoiesis
neuron differentiation
hair follicle morphogenesis
neuron projection development
interferon-gamma production
mRNA transcription from RNA polymerase II promoter
regulation of cell differentiation
negative regulation of cell cycle
cell maturation
negative regulation of epithelial cell proliferation
positive regulation of extrinsic apoptotic signaling pathway
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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