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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (Paraffin) (IHC (P)) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
S100A12 Fusion Protein Ag9961 (1-92 aa encoded by BC070294) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.37 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MTKLEEHLE GIVNIFHQYS VRKGHFDTLS KGELKQLLTK ELANTIKNIK DKAVIDEIFQ GLDANQDEQV DFQEFISLVA IALKAAHYHT HKE (1-92 aa encoded by BC070294)
S100A12 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A12 is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. S100A12 is also a ligand for RAGE. Interaction with RAGE on mononuclear phagocytes, lymphocytes and endothelium triggers cellular activation. Nuclear factor kappa B, a key transcription factor for inflammatory events, is activated by S100A12/RAGE. S100A12 has also been shown to have anti-microbial properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAAF1; CAGC; Calcitermin; Calcium-binding protein in amniotic fluid 1; calgranulin C; Calgranulin-C; CGRP; EN RAGE; EN-RAGE; Extracellular newly identified RAGE-binding protein; Migration inhibitory factor-related protein 6; MRP-6; Neutrophil S100 protein; Protein S100 A12; Protein S100-A12; S100 calcium-binding protein A12; S100 calcium-binding protein A12 (calgranulin C)
Gene Aliases: CAAF1; CAGC; CGRP; ENRAGE; MRP-6; MRP6; p6; S100A12
UniProt ID: (Human) P80511
Entrez Gene ID: (Human) 6283
Molecular Function:
calmodulin-related
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