OPA1-15004 detects S1P1 from human samples.
OPA1-15004 has been successfully used in Western blotting and immunohistochemistry (paraffin) procedures.
Positive Control: Heart, Vessel
The OPA1-15004 immunogen is a synthetic peptide, KLH conjugated, corresponding to the C-terminal domain of human S1P1.
Store at 4°C short term. For extended storage aliquot and store at -20°C or below. Avoid freeze-thaw cycles.
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD363; EDG1; Endothelial differentiation G-protein coupled receptor 1; Endothelial Differentiation Gene 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; S1P receptor 1; S1P receptor Edg-1; S1PR1; Sphingolipid Receptor 1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine 1-phosphate receptor EDG1
Gene Aliases: CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; S1P1; S1PR1
UniProt ID: (Human) P21453
Entrez Gene ID: (Human) 1901