Keep as concentrated solution.
Positive Control: HepG2, mouse liver.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
S1P1 is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that is coupled to the G(i) subclass of heteromeric G proteins. S1P1 signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. It plays an important role in cell migration via its role in the reorganization of the actin cytoskeleton and formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. S1P1 is required for normal chemotaxis toward sphingosine 1-phosphate, normal embryonic heart development, and normal cardiac morphogenesis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 1 antibody; CD363; CHEDG1 antibody; D1S3362 antibody; ECGF1 antibody; EDG-1 antibody; EDG1 antibody; endothelial differentiation; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation G-protein coupled receptor 1 antibody; endothelial differentiation sphingolipid G-protein-coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121 antibody; Lysophospholipid receptor B1; S1P receptor 1; S1P receptor 1 antibody; S1P receptor Edg-1; S1P receptor Edg-1 antibody; S1P1 antibody; S1PR1 antibody; sphingolipid G-protein-coupled receptor; Sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor 1 antibody; Sphingosine 1-phosphate receptor Edg-1; sphingosine 1-phosphate receptor Edg-1 antibody; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor EDG1 antibody; sphingosine-1-phosphate receptor 1 antibody
Gene Aliases: AI849002; CD363; CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; Lpb1; S1p; S1P1; S1PR1