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Abnova
SAG Polyclonal Antibody, MaxPab™
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Product Details
H00006295-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SAG (AAI56657.1, 1 a.a. approximately 405 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MAASGKTSKS EPNHVIFKKI SRDKSVTIYL GNRDYIDHVS QVQPVDGVVL VDPDLVKGKK VYVTLTCAFR YGQEDIDVIG LTFRRDLYFS RVQVYPPVGA ASTPTKLQES LLKKLGSNTY PFLLTFPDYL PCSVMLQPAP QDSGKSCGVD FEVKAFATDS TDAEEDKIPK KSSVRLLIRK VQHAPLEMGP QPRAEAAWQF FMSDKPLHLA VSLNKEIYFH GEPIPVTVTV TNNTEKTVKK IKAFVEQVAN VVLYSSDYYV KPVAMEEAQE KVPPNSTLTK TLTLLPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YQIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPAKE SYQDANLVFE EFARHNLKDA GEAEEGKRDK NDVDE
Target Information
S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 48 kDa protein; arrestin 1; arrestin-1; DKFZp686D1084; DKFZp686I1383; Retinal S-antigen; retinal S-antigen (48 KDa protein); rod arrestin; Rod photoreceptor arrestin; S-AG; S-antigen; retina and pineal gland (arrestin); S-arrestin
Gene Aliases: RP47; S-AG; SAG
UniProt ID: (Human) P10523
Entrez Gene ID: (Human) 6295
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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