Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. [UniProt]
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Protein Aliases: Ceramide phosphoethanolamine synthase; CPE synthase; epididymis luminal protein 177; epididymis secretory sperm binding protein Li 181mP; FLJ25082; HEL-S-181mP; RP11-487I5.5; SAM domain-containing protein 8; SMSr; sphingomyelin synthase related; Sphingomyelin synthase-related protein 1; Sterile alpha motif domain-containing protein 8
Gene Aliases: HEL-177; SAMD8; SMSr
UniProt ID: (Human) Q96LT4
Entrez Gene ID: (Human) 142891