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Proteintech
SAMHD1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
12586-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SAMHD1 Fusion Protein Ag3287 (1-314 aa encoded by BC036450)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MQRADSEQP SKRPRCDDSP RTPSNTPSAE ADWSPGLELH PDYKTWGPEQ VCSFLRRGGF EEPVLLKNIR ENEITGALLP CLDESRFENL GVSSLGERKK LLSYIQRLVQ IHVDTMKVIN DPIHGHIELH PLLVRIIDTP QFQRLRYIKQ LGGGYYVFPG ASHNRFEHSL GVGYLAGCLV HALGEKQPEL QISERDVLCV QIAGLCHDLG HGPFSHMFDG RFIPLARPEV KWTHEQGSVM MFEHLINSNG IKPVMEQYGL IPEEDICFIK EQIVGPLESP VEDSLWPYKG RPENKSFLYE IVSNKRNGID VDKWD (1-314 aa encoded by BC036450)
Target Information
This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: dendritic cell-derived IFNG-induced protein; dNTPase; IFN-gamma induced; interferon-gamma-inducible protein Mg11; monocyte protein 5; RP1-132F21.1; SAM domain and HD domain 1; SAM domain and HD domain, 1; SAM domain and HD domain-containing protein 1; unknown intracellular protein; unnamed protein product
Gene Aliases: CHBL2; DCIP; E330031J07Rik; HDDC1; hSAMHD1; Mg11; MOP-5; mSAMHD1; SBBI88
UniProt ID: (Human) Q9Y3Z3, (Mouse) Q60710
Entrez Gene ID: (Human) 25939, (Mouse) 56045, (Rat) 311580
double-strand break repair via homologous recombination
dGTP catabolic process
immune response
cellular response to DNA damage stimulus
deoxyribonucleotide catabolic process
somatic hypermutation of immunoglobulin genes
regulation of innate immune response
dATP catabolic process
protein homotetramerization
defense response to virus
negative regulation of type I interferon-mediated signaling pathway
DNA strand resection involved in replication fork processing
modulation by host of viral RNA genome replication
positive regulation of transcription, DNA-templated
negative regulation of viral life cycle
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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