Product References
IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing.
EMBO reports
Papa G,Albecka A,Mallery D,Vaysburd M,Renner N,James LC
Thu May 04 00:00:00 UTC 2023
SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis.
Frontiers in immunology
Gutiérrez-Chamorro L,Felip E,Bernat-Peguera A,Ezeonwumelu IJ,Teruel I,Martínez-Cardús A,Clotet B,Riveira-Muñoz E,Romeo M,Margelí M,Ballana E
Tue Feb 28 00:00:00 UTC 2023
iPS cell-derived model to study the interaction between tissue macrophage and HIV-1.
Journal of leukocyte biology
Eltalkhawy YM,Takahashi N,Ariumi Y,Shimizu J,Miyazaki K,Senju S,Suzu S
Sat Jul 01 00:00:00 UTC 2023
Modulation of DNA Damage Response by SAM and HD Domain Containing Deoxynucleoside Triphosphate Triphosphohydrolase (SAMHD1) Determines Prognosis and Treatment Efficacy in Different Solid Tumor Types.
Cancers
Felip E,Gutiérrez-Chamorro L,Gómez M,Garcia-Vidal E,Romeo M,Morán T,Layos L,Pérez-Roca L,Riveira-Muñoz E,Clotet B,Fernandez PL,Mesía R,Martínez-Cardús A,Ballana E,Margelí M
Thu Jan 27 00:00:00 UTC 2022
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.
Cell death & disease
Zhang F,Sun J,Tang X,Liang Y,Jiao Q,Yu B,Dai Z,Yuan X,Li J,Yan J,Zhang Z,Fan S,Wang M,Hu H,Zhang C,Lv XB
Fri Jul 08 00:00:00 UTC 2022
Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML.
Cell death & disease
Zhang F,Sun J,Tang X,Liang Y,Jiao Q,Yu B,Dai Z,Yuan X,Li J,Yan J,Zhang Z,Fan S,Wang M,Hu H,Zhang C,Lv XB
Fri Jul 08 00:00:00 UTC 2022
N6-methyladenosine demethylase FTO regulates inflammatory cytokine secretion and tight junctions in retinal pigment epithelium cells.
Clinical immunology (Orlando, Fla.)
Tang S,Meng J,Tan J,Liu X,Zhou H,Li N,Hou S
Mon Aug 01 00:00:00 UTC 2022
Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization.
Virusdisease
Sleman S,Najmuldeen H,Hao H,Jalal P,Saeed N,Othman D,Qian Z
Thu Dec 01 00:00:00 UTC 2022
Human cytomegalovirus UL24 and UL43 products participate in SAMHD1 subcellular localization.
Virusdisease
Sleman S,Najmuldeen H,Hao H,Jalal P,Saeed N,Othman D,Qian Z
Thu Dec 01 00:00:00 UTC 2022
Inhibitory and Stimulatory Effects of IL-32 on HIV-1 Infection.
Journal of immunology (Baltimore, Md. : 1950)
Nasser H,Takahashi N,Eltalkhawy YM,Reda O,Lotfi S,Nasu K,Sakuragi JI,Suzu S
Thu Sep 01 00:00:00 UTC 2022
1,25(OH)2D3 Promotes Macrophage Efferocytosis Partly by Upregulating ASAP2 Transcription via the VDR-Bound Enhancer Region and ASAP2 May Affect Antiviral Immunity.
Nutrients
Shi H,Duan J,Wang J,Li H,Wu Z,Wang S,Wu X,Lu M
Mon Nov 21 00:00:00 UTC 2022
Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma.
Virchows Archiv : an international journal of pathology
Merrien M,Wasik AM,Ljung E,Morsy MHA,de Matos Rodrigues J,Carlsten M,Rassidakis GZ,Christensson B,Kolstad A,Jerkeman M,Ek S,Herold N,Wahlin BE,Sander B
Tue Mar 01 00:00:00 UTC 2022
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
International journal of cancer
Roider T,Wang X,Hüttl K,Müller-Tidow C,Klapper W,Rosenwald A,Stewart JP,de Castro DG,Dreger P,Hermine O,Kluin-Nelemans HC,Grabe N,Dreyling M,Pott C,Ott G,Hoster E,Dietrich S
Fri Jan 01 00:00:00 UTC 2021
The impact of SAMHD1 expression and mutation status in mantle cell lymphoma: An analysis of the MCL Younger and Elderly trial.
International journal of cancer
Roider T,Wang X,Hüttl K,Müller-Tidow C,Klapper W,Rosenwald A,Stewart JP,de Castro DG,Dreger P,Hermine O,Kluin-Nelemans HC,Grabe N,Dreyling M,Pott C,Ott G,Hoster E,Dietrich S
Fri Jan 01 00:00:00 UTC 2021
Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins.
Cell reports
Hiatt J,Cavero DA,McGregor MJ,Zheng W,Budzik JM,Roth TL,Haas KM,Wu D,Rathore U,Meyer-Franke A,Bouzidi MS,Shifrut E,Lee Y,Kumar VE,Dang EV,Gordon DE,Wojcechowskyj JA,Hultquist JF,Fontaine KA,Pillai SK,Cox JS,Ernst JD,Krogan NJ,Marson A
Tue May 11 00:00:00 UTC 2021
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Journal of experimental & clinical cancer research : CR
Rothenburger T,Thomas D,Schreiber Y,Wratil PR,Pflantz T,Knecht K,Digianantonio K,Temple J,Schneider C,Baldauf HM,McLaughlin KM,Rothweiler F,Bilen B,Farmand S,Bojkova D,Costa R,Ferreirós N,Geisslinger G,Oellerich T,Xiong Y,Keppler OT,Wass MN,Michaelis M,Cinatl J
Tue Oct 12 00:00:00 UTC 2021
Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cells.
Journal of experimental & clinical cancer research : CR
Rothenburger T,Thomas D,Schreiber Y,Wratil PR,Pflantz T,Knecht K,Digianantonio K,Temple J,Schneider C,Baldauf HM,McLaughlin KM,Rothweiler F,Bilen B,Farmand S,Bojkova D,Costa R,Ferreirós N,Geisslinger G,Oellerich T,Xiong Y,Keppler OT,Wass MN,Michaelis M,Cinatl J
Tue Oct 12 00:00:00 UTC 2021
Disrupting HIV-1 capsid formation causes cGAS sensing of viral DNA.
The EMBO journal
Sumner RP,Harrison L,Touizer E,Peacock TP,Spencer M,Zuliani-Alvarez L,Towers GJ
Thu Oct 15 00:00:00 UTC 2020
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
EMBO reports
Li Z,Huan C,Wang H,Liu Y,Liu X,Su X,Yu J,Zhao Z,Yu XF,Zheng B,Zhang W
Tue Jan 07 00:00:00 UTC 2020
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy.
EMBO molecular medicine
Rudd SG,Tsesmetzis N,Sanjiv K,Paulin CB,Sandhow L,Kutzner J,Hed Myrberg I,Bunten SS,Axelsson H,Zhang SM,Rasti A,Mäkelä P,Coggins SA,Tao S,Suman S,Branca RM,Mermelekas G,Wiita E,Lee S,Walfridsson J,Schinazi RF,Kim B,Lehtiö J,Rassidakis GZ,Pokrovskaja Tamm K,Warpman-Berglund U,Heyman M,Grandér D,Lehmann S,Lundbäck T,Qian H,Henter JI,Schaller T,Helleday T,Herold N
Fri Mar 06 00:00:00 UTC 2020
Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.
eLife
Neidleman J,Luo X,Frouard J,Xie G,Hsiao F,Ma T,Morcilla V,Lee A,Telwatte S,Thomas R,Tamaki W,Wheeler B,Hoh R,Somsouk M,Vohra P,Milush J,James KS,Archin NM,Hunt PW,Deeks SG,Yukl SA,Palmer S,Greene WC,Roan NR
Tue Sep 29 00:00:00 UTC 2020
SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity.
PLoS pathogens
De Meo S,Dell'Oste V,Molfetta R,Tassinari V,Lotti LV,Vespa S,Pignoloni B,Covino DA,Fantuzzi L,Bona R,Zingoni A,Nardone I,Biolatti M,Coscia A,Paolini R,Benkirane M,Edfors F,Sandalova T,Achour A,Hiscott J,Landolfo S,Santoni A,Cerboni C
Tue Sep 01 00:00:00 UTC 2020
SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine.
Communications biology
Rothenburger T,McLaughlin KM,Herold T,Schneider C,Oellerich T,Rothweiler F,Feber A,Fenton TR,Wass MN,Keppler OT,Michaelis M,Cinatl J
Wed Jun 24 00:00:00 UTC 2020
Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy.
Cancers
Castellví M,Felip E,Ezeonwumelu IJ,Badia R,Garcia-Vidal E,Pujantell M,Gutiérrez-Chamorro L,Teruel I,Martínez-Cardús A,Clotet B,Riveira-Muñoz E,Margelí M,Ballana E
Wed Mar 18 00:00:00 UTC 2020
TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages.
Cell reports
Mlcochova P,Winstone H,Zuliani-Alvarez L,Gupta RK
Tue Mar 24 00:00:00 UTC 2020
SAMHD1-deficient fibroblasts from Aicardi-Goutières Syndrome patients can escape senescence and accumulate mutations.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Franzolin E,Coletta S,Ferraro P,Pontarin G,D'Aronco G,Stevanoni M,Palumbo E,Cagnin S,Bertoldi L,Feltrin E,Valle G,Russo A,Bianchi V,Rampazzo C
Wed Jan 01 00:00:00 UTC 2020
Selective inactivation of hypomethylating agents by SAMHD1 provides a rationale for therapeutic stratification in AML.
Nature communications
Oellerich T,Schneider C,Thomas D,Knecht KM,Buzovetsky O,Kaderali L,Schliemann C,Bohnenberger H,Angenendt L,Hartmann W,Wardelmann E,Rothenburger T,Mohr S,Scheich S,Comoglio F,Wilke A,Ströbel P,Serve H,Michaelis M,Ferreirós N,Geisslinger G,Xiong Y,Keppler OT,Cinatl J
Fri Aug 02 00:00:00 UTC 2019
Insights into Innate Sensing of Prototype Foamy Viruses in Myeloid Cells.
Viruses
Bergez M,Weber J,Riess M,Erdbeer A,Seifried J,Stanke N,Munz C,Hornung V,König R,Lindemann D
Tue Nov 26 00:00:00 UTC 2019
ISG15 Deficiency Enhances HIV-1 Infection by Accumulating Misfolded p53.
mBio
Osei Kuffour E,König R,Häussinger D,Schulz WA,Münk C
Tue Aug 27 00:00:00 UTC 2019
Interference with SAMHD1 Restores Late Gene Expression of Modified Vaccinia Virus Ankara in Human Dendritic Cells and Abrogates Type I Interferon Expression.
Journal of virology
Sliva K,Martin J,von Rhein C,Herrmann T,Weyrich A,Toda M,Schnierle BS
Fri Nov 15 00:00:00 UTC 2019
Interferon Gamma Inhibits Varicella-Zoster Virus Replication in a Cell Line-Dependent Manner.
Journal of virology
Shakya AK,O'Callaghan DJ,Kim SK
Sat Jun 15 00:00:00 UTC 2019
Human cytomegalovirus overcomes SAMHD1 restriction in macrophages via pUL97.
Nature microbiology
Businger R,Deutschmann J,Gruska I,Milbradt J,Wiebusch L,Gramberg T,Schindler M
Sun Dec 01 00:00:00 UTC 2019
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
Journal of virology
Osei Kuffour E,Schott K,Jaguva Vasudevan AA,Holler J,Schulz WA,Lang PA,Lang KS,Kim B,Häussinger D,König R,Münk C
Mon Oct 15 00:00:00 UTC 2018
USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1.
Journal of virology
Osei Kuffour E,Schott K,Jaguva Vasudevan AA,Holler J,Schulz WA,Lang PA,Lang KS,Kim B,Häussinger D,König R,Münk C
Mon Oct 15 00:00:00 UTC 2018
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592.
Cell cycle (Georgetown, Tex.)
Tramentozzi E,Ferraro P,Hossain M,Stillman B,Bianchi V,Pontarin G
Tue Dec 17 00:00:00 UTC 2019
The dNTP triphosphohydrolase activity of SAMHD1 persists during S-phase when the enzyme is phosphorylated at T592.
Cell cycle (Georgetown, Tex.)
Tramentozzi E,Ferraro P,Hossain M,Stillman B,Bianchi V,Pontarin G
Tue Dec 17 00:00:00 UTC 2019
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Biochemical and biophysical research communications
Medeiros AC,Soares CS,Coelho PO,Vieira NA,Baqui MMA,Teixeira FR,Gomes MD
Wed May 23 00:00:00 UTC 2018
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Biochemical and biophysical research communications
Medeiros AC,Soares CS,Coelho PO,Vieira NA,Baqui MMA,Teixeira FR,Gomes MD
Wed May 23 00:00:00 UTC 2018
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Biochemical and biophysical research communications
Medeiros AC,Soares CS,Coelho PO,Vieira NA,Baqui MMA,Teixeira FR,Gomes MD
Wed May 23 00:00:00 UTC 2018
DNA damage response signaling does not trigger redistribution of SAMHD1 to nuclear foci.
Biochemical and biophysical research communications
Medeiros AC,Soares CS,Coelho PO,Vieira NA,Baqui MMA,Teixeira FR,Gomes MD
Wed May 23 00:00:00 UTC 2018
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Blood cancer journal
Rassidakis GZ,Herold N,Myrberg IH,Tsesmetzis N,Rudd SG,Henter JI,Schaller T,Ng SB,Chng WJ,Yan B,Ng CH,Ravandi F,Andreeff M,Kantarjian HM,Medeiros LJ,Xagoraris I,Khoury JD
Fri Oct 19 00:00:00 UTC 2018
Low-level expression of SAMHD1 in acute myeloid leukemia (AML) blasts correlates with improved outcome upon consolidation chemotherapy with high-dose cytarabine-based regimens.
Blood cancer journal
Rassidakis GZ,Herold N,Myrberg IH,Tsesmetzis N,Rudd SG,Henter JI,Schaller T,Ng SB,Chng WJ,Yan B,Ng CH,Ravandi F,Andreeff M,Kantarjian HM,Medeiros LJ,Xagoraris I,Khoury JD
Fri Oct 19 00:00:00 UTC 2018
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages.
Viruses
Bejarano DA,Puertas MC,Börner K,Martinez-Picado J,Müller B,Kräusslich HG
Sat Nov 10 00:00:00 UTC 2018
Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages.
Viruses
Bejarano DA,Puertas MC,Börner K,Martinez-Picado J,Müller B,Kräusslich HG
Sat Nov 10 00:00:00 UTC 2018
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proceedings of the National Academy of Sciences of the United States of America
Knecht KM,Buzovetsky O,Schneider C,Thomas D,Srikanth V,Kaderali L,Tofoleanu F,Reiss K,Ferreirós N,Geisslinger G,Batista VS,Ji X,Cinatl J,Keppler OT,Xiong Y
Tue Oct 23 00:00:00 UTC 2018
Inhibition of HIV early replication by the p53 and its downstream gene p21.
Virology journal
Shi B,Sharifi HJ,DiGrigoli S,Kinnetz M,Mellon K,Hu W,de Noronha CMC
Tue Mar 27 00:00:00 UTC 2018
Inhibition of HIV early replication by the p53 and its downstream gene p21.
Virology journal
Shi B,Sharifi HJ,DiGrigoli S,Kinnetz M,Mellon K,Hu W,de Noronha CMC
Tue Mar 27 00:00:00 UTC 2018
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Nature medicine
Herold N,Rudd SG,Ljungblad L,Sanjiv K,Myrberg IH,Paulin CB,Heshmati Y,Hagenkort A,Kutzner J,Page BD,Calderón-Montaño JM,Loseva O,Jemth AS,Bulli L,Axelsson H,Tesi B,Valerie NC,Höglund A,Bladh J,Wiita E,Sundin M,Uhlin M,Rassidakis G,Heyman M,Tamm KP,Warpman-Berglund U,Walfridsson J,Lehmann S,Grandér D,Lundbäck T,Kogner P,Henter JI,Helleday T,Schaller T
Wed Feb 01 00:00:00 UTC 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Nature medicine
Herold N,Rudd SG,Ljungblad L,Sanjiv K,Myrberg IH,Paulin CB,Heshmati Y,Hagenkort A,Kutzner J,Page BD,Calderón-Montaño JM,Loseva O,Jemth AS,Bulli L,Axelsson H,Tesi B,Valerie NC,Höglund A,Bladh J,Wiita E,Sundin M,Uhlin M,Rassidakis G,Heyman M,Tamm KP,Warpman-Berglund U,Walfridsson J,Lehmann S,Grandér D,Lundbäck T,Kogner P,Henter JI,Helleday T,Schaller T
Wed Feb 01 00:00:00 UTC 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Nature medicine
Herold N,Rudd SG,Ljungblad L,Sanjiv K,Myrberg IH,Paulin CB,Heshmati Y,Hagenkort A,Kutzner J,Page BD,Calderón-Montaño JM,Loseva O,Jemth AS,Bulli L,Axelsson H,Tesi B,Valerie NC,Höglund A,Bladh J,Wiita E,Sundin M,Uhlin M,Rassidakis G,Heyman M,Tamm KP,Warpman-Berglund U,Walfridsson J,Lehmann S,Grandér D,Lundbäck T,Kogner P,Henter JI,Helleday T,Schaller T
Wed Feb 01 00:00:00 UTC 2017
Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.
Nature medicine
Herold N,Rudd SG,Ljungblad L,Sanjiv K,Myrberg IH,Paulin CB,Heshmati Y,Hagenkort A,Kutzner J,Page BD,Calderón-Montaño JM,Loseva O,Jemth AS,Bulli L,Axelsson H,Tesi B,Valerie NC,Höglund A,Bladh J,Wiita E,Sundin M,Uhlin M,Rassidakis G,Heyman M,Tamm KP,Warpman-Berglund U,Walfridsson J,Lehmann S,Grandér D,Lundbäck T,Kogner P,Henter JI,Helleday T,Schaller T
Wed Feb 01 00:00:00 UTC 2017
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
Wed Feb 01 00:00:00 UTC 2017
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
Wed Feb 01 00:00:00 UTC 2017
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
Wed Feb 01 00:00:00 UTC 2017
SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.
Nature medicine
Schneider C,Oellerich T,Baldauf HM,Schwarz SM,Thomas D,Flick R,Bohnenberger H,Kaderali L,Stegmann L,Cremer A,Martin M,Lohmeyer J,Michaelis M,Hornung V,Schliemann C,Berdel WE,Hartmann W,Wardelmann E,Comoglio F,Hansmann ML,Yakunin AF,Geisslinger G,Ströbel P,Ferreirós N,Serve H,Keppler OT,Cinatl J
Wed Feb 01 00:00:00 UTC 2017
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America
Baldauf HM,Stegmann L,Schwarz SM,Ambiel I,Trotard M,Martin M,Burggraf M,Lenzi GM,Lejk H,Pan X,Fregoso OI,Lim ES,Abraham L,Nguyen LA,Rutsch F,König R,Kim B,Emerman M,Fackler OT,Keppler OT
Tue Mar 07 00:00:00 UTC 2017
Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.
Proceedings of the National Academy of Sciences of the United States of America
Baldauf HM,Stegmann L,Schwarz SM,Ambiel I,Trotard M,Martin M,Burggraf M,Lenzi GM,Lejk H,Pan X,Fregoso OI,Lim ES,Abraham L,Nguyen LA,Rutsch F,König R,Kim B,Emerman M,Fackler OT,Keppler OT
Tue Mar 07 00:00:00 UTC 2017
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Antiviral research
Badia R,Pujantell M,Torres-Torronteras J,Menéndez-Arias L,Martí R,Ruzo A,Pauls E,Clotet B,Ballana E,Esté JA,Riveira-Muñoz E
Thu Jun 01 00:00:00 UTC 2017
SAMHD1 is active in cycling cells permissive to HIV-1 infection.
Antiviral research
Badia R,Pujantell M,Torres-Torronteras J,Menéndez-Arias L,Martí R,Ruzo A,Pauls E,Clotet B,Ballana E,Esté JA,Riveira-Muñoz E
Thu Jun 01 00:00:00 UTC 2017
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
The Journal of biological chemistry
Riess M,Fuchs NV,Idica A,Hamdorf M,Flory E,Pedersen IM,König R
Fri Jan 06 00:00:00 UTC 2017
Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30a.
The Journal of biological chemistry
Riess M,Fuchs NV,Idica A,Hamdorf M,Flory E,Pedersen IM,König R
Fri Jan 06 00:00:00 UTC 2017
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Journal of the International AIDS Society
Bolduan S,Koppensteiner H,Businger R,Rebensburg S,Kunze C,Brack-Werner R,Draenert R,Schindler M
Tue Sep 19 00:00:00 UTC 2017
T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.
Journal of the International AIDS Society
Bolduan S,Koppensteiner H,Businger R,Rebensburg S,Kunze C,Brack-Werner R,Draenert R,Schindler M
Tue Sep 19 00:00:00 UTC 2017
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Scientific reports
Sommer AF,Rivière L,Qu B,Schott K,Riess M,Ni Y,Shepard C,Schnellbächer E,Finkernagel M,Himmelsbach K,Welzel K,Kettern N,Donnerhak C,Münk C,Flory E,Liese J,Kim B,Urban S,König R
Fri May 27 00:00:00 UTC 2016
Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.
Scientific reports
Sommer AF,Rivière L,Qu B,Schott K,Riess M,Ni Y,Shepard C,Schnellbächer E,Finkernagel M,Himmelsbach K,Welzel K,Kettern N,Donnerhak C,Münk C,Flory E,Liese J,Kim B,Urban S,König R
Fri May 27 00:00:00 UTC 2016
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.
Scientific reports
Fu W,Qiu C,Zhou M,Zhu L,Yang Y,Qiu C,Zhang L,Xu X,Wang Y,Xu J,Zhang X
Tue Dec 06 00:00:00 UTC 2016
Immune Activation Influences SAMHD1 Expression and Vpx-mediated SAMHD1 Degradation during Chronic HIV-1 Infection.
Scientific reports
Fu W,Qiu C,Zhou M,Zhu L,Yang Y,Qiu C,Zhang L,Xu X,Wang Y,Xu J,Zhang X
Tue Dec 06 00:00:00 UTC 2016
SAMHD1 prevents autoimmunity by maintaining genome stability.
Annals of the rheumatic diseases
Kretschmer S,Wolf C,König N,Staroske W,Guck J,Häusler M,Luksch H,Nguyen LA,Kim B,Alexopoulou D,Dahl A,Rapp A,Cardoso MC,Shevchenko A,Lee-Kirsch MA
Sun Mar 01 00:00:00 UTC 2015
SAMHD1 prevents autoimmunity by maintaining genome stability.
Annals of the rheumatic diseases
Kretschmer S,Wolf C,König N,Staroske W,Guck J,Häusler M,Luksch H,Nguyen LA,Kim B,Alexopoulou D,Dahl A,Rapp A,Cardoso MC,Shevchenko A,Lee-Kirsch MA
Sun Mar 01 00:00:00 UTC 2015
SAMHD1 prevents autoimmunity by maintaining genome stability.
Annals of the rheumatic diseases
Kretschmer S,Wolf C,König N,Staroske W,Guck J,Häusler M,Luksch H,Nguyen LA,Kim B,Alexopoulou D,Dahl A,Rapp A,Cardoso MC,Shevchenko A,Lee-Kirsch MA
Sun Mar 01 00:00:00 UTC 2015
SAMHD1 prevents autoimmunity by maintaining genome stability.
Annals of the rheumatic diseases
Kretschmer S,Wolf C,König N,Staroske W,Guck J,Häusler M,Luksch H,Nguyen LA,Kim B,Alexopoulou D,Dahl A,Rapp A,Cardoso MC,Shevchenko A,Lee-Kirsch MA
Sun Mar 01 00:00:00 UTC 2015
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
PLoS pathogens
Shingai M,Welbourn S,Brenchley JM,Acharya P,Miyagi E,Plishka RJ,Buckler-White A,Kwong PD,Nishimura Y,Strebel K,Martin MA
Fri May 01 00:00:00 UTC 2015
The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells.
PLoS pathogens
Shingai M,Welbourn S,Brenchley JM,Acharya P,Miyagi E,Plishka RJ,Buckler-White A,Kwong PD,Nishimura Y,Strebel K,Martin MA
Fri May 01 00:00:00 UTC 2015
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.
Journal of virology
de Castro-Amarante MF,Pise-Masison CA,McKinnon K,Washington Parks R,Galli V,Omsland M,Andresen V,Massoud R,Brunetto G,Caruso B,Venzon D,Jacobson S,Franchini G
Wed Nov 25 00:00:00 UTC 2015
Human T Cell Leukemia Virus Type 1 Infection of the Three Monocyte Subsets Contributes to Viral Burden in Humans.
Journal of virology
de Castro-Amarante MF,Pise-Masison CA,McKinnon K,Washington Parks R,Galli V,Omsland M,Andresen V,Massoud R,Brunetto G,Caruso B,Venzon D,Jacobson S,Franchini G
Wed Nov 25 00:00:00 UTC 2015
SAMHD1's protein expression profile in humans.
Journal of leukocyte biology
Schmidt S,Schenkova K,Adam T,Erikson E,Lehmann-Koch J,Sertel S,Verhasselt B,Fackler OT,Lasitschka F,Keppler OT
Wed Jul 01 00:00:00 UTC 2015
SAMHD1's protein expression profile in humans.
Journal of leukocyte biology
Schmidt S,Schenkova K,Adam T,Erikson E,Lehmann-Koch J,Sertel S,Verhasselt B,Fackler OT,Lasitschka F,Keppler OT
Wed Jul 01 00:00:00 UTC 2015
SAMHD1's protein expression profile in humans.
Journal of leukocyte biology
Schmidt S,Schenkova K,Adam T,Erikson E,Lehmann-Koch J,Sertel S,Verhasselt B,Fackler OT,Lasitschka F,Keppler OT
Wed Jul 01 00:00:00 UTC 2015
SAMHD1's protein expression profile in humans.
Journal of leukocyte biology
Schmidt S,Schenkova K,Adam T,Erikson E,Lehmann-Koch J,Sertel S,Verhasselt B,Fackler OT,Lasitschka F,Keppler OT
Wed Jul 01 00:00:00 UTC 2015
Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.
Molecular medicine reports
Zhu M,Lu J,Dong X,Zheng N,Li T,Chen Z,Pan X,Zhu Y,Yan H,Shen Y,Ying S,Hu C
Sun Nov 01 00:00:00 UTC 2015
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
PloS one
Witkowski W,Vermeire J,Landi A,Naessens E,Vanderstraeten H,Nauwynck H,Favoreel H,Verhasselt B
Thu May 05 00:00:00 UTC 2016
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
PloS one
Witkowski W,Vermeire J,Landi A,Naessens E,Vanderstraeten H,Nauwynck H,Favoreel H,Verhasselt B
Thu May 05 00:00:00 UTC 2016
HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.
Retrovirology
Chauveau L,Puigdomenech I,Ayinde D,Roesch F,Porrot F,Bruni D,Visseaux B,Descamps D,Schwartz O
Tue Jan 13 00:00:00 UTC 2015
HIV-2 infects resting CD4+ T cells but not monocyte-derived dendritic cells.
Retrovirology
Chauveau L,Puigdomenech I,Ayinde D,Roesch F,Porrot F,Bruni D,Visseaux B,Descamps D,Schwartz O
Tue Jan 13 00:00:00 UTC 2015
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.
Immunity
Calantone N,Wu F,Klase Z,Deleage C,Perkins M,Matsuda K,Thompson EA,Ortiz AM,Vinton CL,Ourmanov I,Loré K,Douek DC,Estes JD,Hirsch VM,Brenchley JM
Thu Sep 18 00:00:00 UTC 2014
Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells.
Immunity
Calantone N,Wu F,Klase Z,Deleage C,Perkins M,Matsuda K,Thompson EA,Ortiz AM,Vinton CL,Ourmanov I,Loré K,Douek DC,Estes JD,Hirsch VM,Brenchley JM
Thu Sep 18 00:00:00 UTC 2014
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy
Ballana E,Badia R,Terradas G,Torres-Torronteras J,Ruiz A,Pauls E,Riveira-Muñoz E,Clotet B,Martí R,Esté JA
Fri Aug 01 00:00:00 UTC 2014
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy
Ballana E,Badia R,Terradas G,Torres-Torronteras J,Ruiz A,Pauls E,Riveira-Muñoz E,Clotet B,Martí R,Esté JA
Fri Aug 01 00:00:00 UTC 2014
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy
Ballana E,Badia R,Terradas G,Torres-Torronteras J,Ruiz A,Pauls E,Riveira-Muñoz E,Clotet B,Martí R,Esté JA
Fri Aug 01 00:00:00 UTC 2014
SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors.
Antimicrobial agents and chemotherapy
Ballana E,Badia R,Terradas G,Torres-Torronteras J,Ruiz A,Pauls E,Riveira-Muñoz E,Clotet B,Martí R,Esté JA
Fri Aug 01 00:00:00 UTC 2014
Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity.
AIDS (London, England)
Pauls E,Badia R,Torres-Torronteras J,Ruiz A,Permanyer M,Riveira-Muñoz E,Clotet B,Marti R,Ballana E,Esté JA
Wed Sep 24 00:00:00 UTC 2014
Inhibition of Hepatitis B virus replication by SAMHD1.
Biochemical and biophysical research communications
Chen Z,Zhu M,Pan X,Zhu Y,Yan H,Jiang T,Shen Y,Dong X,Zheng N,Lu J,Ying S,Shen Y
Fri Aug 08 00:00:00 UTC 2014
Inhibition of Hepatitis B virus replication by SAMHD1.
Biochemical and biophysical research communications
Chen Z,Zhu M,Pan X,Zhu Y,Yan H,Jiang T,Shen Y,Dong X,Zheng N,Lu J,Ying S,Shen Y
Fri Aug 08 00:00:00 UTC 2014
Inhibition of Hepatitis B virus replication by SAMHD1.
Biochemical and biophysical research communications
Chen Z,Zhu M,Pan X,Zhu Y,Yan H,Jiang T,Shen Y,Dong X,Zheng N,Lu J,Ying S,Shen Y
Fri Aug 08 00:00:00 UTC 2014
Inhibition of Hepatitis B virus replication by SAMHD1.
Biochemical and biophysical research communications
Chen Z,Zhu M,Pan X,Zhu Y,Yan H,Jiang T,Shen Y,Dong X,Zheng N,Lu J,Ying S,Shen Y
Fri Aug 08 00:00:00 UTC 2014
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Retrovirology
Reinhard C,Bottinelli D,Kim B,Luban J
Sat Feb 01 00:00:00 UTC 2014
Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.
Retrovirology
Reinhard C,Bottinelli D,Kim B,Luban J
Sat Feb 01 00:00:00 UTC 2014
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
Journal of virology
Puigdomènech I,Casartelli N,Porrot F,Schwartz O
Fri Mar 01 00:00:00 UTC 2013
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
Journal of virology
Puigdomènech I,Casartelli N,Porrot F,Schwartz O
Fri Mar 01 00:00:00 UTC 2013
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine
Baldauf HM,Pan X,Erikson E,Schmidt S,Daddacha W,Burggraf M,Schenkova K,Ambiel I,Wabnitz G,Gramberg T,Panitz S,Flory E,Landau NR,Sertel S,Rutsch F,Lasitschka F,Kim B,König R,Fackler OT,Keppler OT
Thu Nov 01 00:00:00 UTC 2012
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine
Baldauf HM,Pan X,Erikson E,Schmidt S,Daddacha W,Burggraf M,Schenkova K,Ambiel I,Wabnitz G,Gramberg T,Panitz S,Flory E,Landau NR,Sertel S,Rutsch F,Lasitschka F,Kim B,König R,Fackler OT,Keppler OT
Thu Nov 01 00:00:00 UTC 2012
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine
Baldauf HM,Pan X,Erikson E,Schmidt S,Daddacha W,Burggraf M,Schenkova K,Ambiel I,Wabnitz G,Gramberg T,Panitz S,Flory E,Landau NR,Sertel S,Rutsch F,Lasitschka F,Kim B,König R,Fackler OT,Keppler OT
Thu Nov 01 00:00:00 UTC 2012
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine
Baldauf HM,Pan X,Erikson E,Schmidt S,Daddacha W,Burggraf M,Schenkova K,Ambiel I,Wabnitz G,Gramberg T,Panitz S,Flory E,Landau NR,Sertel S,Rutsch F,Lasitschka F,Kim B,König R,Fackler OT,Keppler OT
Thu Nov 01 00:00:00 UTC 2012
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Nature medicine
Baldauf HM,Pan X,Erikson E,Schmidt S,Daddacha W,Burggraf M,Schenkova K,Ambiel I,Wabnitz G,Gramberg T,Panitz S,Flory E,Landau NR,Sertel S,Rutsch F,Lasitschka F,Kim B,König R,Fackler OT,Keppler OT
Thu Nov 01 00:00:00 UTC 2012
Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.
Retrovirology
Zhou T,Dang Y,Baker JJ,Zhou J,Zheng YH
Wed Nov 07 00:00:00 UTC 2012
Evidence for Vpr-dependent HIV-1 replication in human CD4+ CEM.NKR T-cells.
Retrovirology
Zhou T,Dang Y,Baker JJ,Zhou J,Zheng YH
Wed Nov 07 00:00:00 UTC 2012
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Human mutation
Thiele H,du Moulin M,Barczyk K,George C,Schwindt W,Nürnberg G,Frosch M,Kurlemann G,Roth J,Nürnberg P,Rutsch F
Mon Nov 01 00:00:00 UTC 2010
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Human mutation
Thiele H,du Moulin M,Barczyk K,George C,Schwindt W,Nürnberg G,Frosch M,Kurlemann G,Roth J,Nürnberg P,Rutsch F
Mon Nov 01 00:00:00 UTC 2010
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Human mutation
Thiele H,du Moulin M,Barczyk K,George C,Schwindt W,Nürnberg G,Frosch M,Kurlemann G,Roth J,Nürnberg P,Rutsch F
Mon Nov 01 00:00:00 UTC 2010
Cerebral arterial stenoses and stroke: novel features of Aicardi-Goutières syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression.
Human mutation
Thiele H,du Moulin M,Barczyk K,George C,Schwindt W,Nürnberg G,Frosch M,Kurlemann G,Roth J,Nürnberg P,Rutsch F
Mon Nov 01 00:00:00 UTC 2010
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.
Nature genetics
Rice GI,Bond J,Asipu A,Brunette RL,Manfield IW,Carr IM,Fuller JC,Jackson RM,Lamb T,Briggs TA,Ali M,Gornall H,Couthard LR,Aeby A,Attard-Montalto SP,Bertini E,Bodemer C,Brockmann K,Brueton LA,Corry PC,Desguerre I,Fazzi E,Cazorla AG,Gener B,Hamel BC,Heiberg A,Hunter M,van der Knaap MS,Kumar R,Lagae L,Landrieu PG,Lourenco CM,Marom D,McDermott MF,van der Merwe W,Orcesi S,Prendiville JS,Rasmussen M,Shalev SA,Soler DM,Shinawi M,Spiegel R,Tan TY,Vanderver A,Wakeling EL,Wassmer E,Whittaker E,Lebon P,Stetson DB,Bonthron DT,Crow YJ
Wed Jul 01 00:00:00 UTC 2009
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.
Nature genetics
Rice GI,Bond J,Asipu A,Brunette RL,Manfield IW,Carr IM,Fuller JC,Jackson RM,Lamb T,Briggs TA,Ali M,Gornall H,Couthard LR,Aeby A,Attard-Montalto SP,Bertini E,Bodemer C,Brockmann K,Brueton LA,Corry PC,Desguerre I,Fazzi E,Cazorla AG,Gener B,Hamel BC,Heiberg A,Hunter M,van der Knaap MS,Kumar R,Lagae L,Landrieu PG,Lourenco CM,Marom D,McDermott MF,van der Merwe W,Orcesi S,Prendiville JS,Rasmussen M,Shalev SA,Soler DM,Shinawi M,Spiegel R,Tan TY,Vanderver A,Wakeling EL,Wassmer E,Whittaker E,Lebon P,Stetson DB,Bonthron DT,Crow YJ
Wed Jul 01 00:00:00 UTC 2009
