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Invitrogen
SAP102 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA1-045
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues G(83) P V P P K P V P G K N T P K L N G(100) of rat SAP102.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-045 detects synapse-associated protein 102 (SAP102) from rat tissues.
PA1-045 has been successfully used in Western blot and immunohistochemistry procedures. By Western blot, this antibody detects an ~102 kDa protein representing SAP102 in rat brain homogenate. Immunohistochemical staining of SAP102 in rat hippocampus yields a pattern consistent with post-synaptic localization.
The PA1-045 immunogen is a synthetic peptide corresponding to residues G(83) P V P P K P V P G K N T P K L N G(100) of rat SAP102. PA1-045 immunizing peptide (Cat. # PEP-023) is available for use in neutralization and control experiments.
Target Information
Synapse-Associated Protein 102 (SAP102) is one of a family of plasma membrane-associated proteins found in synaptic junctions. Like other members of the family, SAP102 has three approximately 90 amino acid repeats called PDZ domains followed by an SH3 domain and a yeast guanylate kinase homology (GuK) domain. It is hypothesized that PDZ-domain interactions play a role in receptor and channel clustering which contributes to neuronal plasticity. SAP102 is believed to participate in the clustering of certain proteins, including NMDA receptors, shaker-type potassium channels at the synaptic membrane in CNS neurons. NMDA receptors and Shaker-type potassium channels both share C-terminal sequence homology consisting of a threonine/serine-X-valine-COOH (T/SXV) motif. Other neuronal proteins that share this motif (beta 1 adrenergic receptor, some serotonin receptors, some sodium channel subunits, and additional potassium channel subunits) may interact with SAP102 by binding to its PDZ domains. Neuronal nitric oxide synthase (nNOS), which lacks the T/SXV motif but which has its own PDZ domain, has been shown to associate with SAP102 in vitro through a pseudo-homotypic PDZ-PDZ interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: discs, large homolog 3; PSD-95/SAP90-related protein 1; SAP-102; SAP102; synapse-associated protein 102
Gene Aliases: Dlgh3
UniProt ID: (Rat) Q62936
Entrez Gene ID: (Rat) 58948
establishment of planar polarity
chemical synaptic transmission
nervous system development
protein localization to synapse
receptor clustering
establishment or maintenance of epithelial cell apical/basal polarity
receptor localization to synapse
cell-cell adhesion
regulation of postsynaptic membrane neurotransmitter receptor levels
maintenance of postsynaptic density structure
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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