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Invitrogen
SAP18 Polyclonal Antibody
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FIGURE: 1 / 3
SAP18 Antibody (PA5-92207) in IHC (P)
Immunohistochemistry analysis of SAP18 in paraffin-embedded mouse brain. Samples were incubated with SAP18 Polyclonal antibody (Product # PA5-92207) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-92207
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 21-172 of human SAP18 (NP_0058612)
Conjugate
Form
Liquid
Concentration
0.91 mg/mL
Amount
91 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: AVESRVTQEE IKKEPEKPID REKTCPLLLR VFTTNNGRHH RMDEFSRGNV PSSELQIYTW MDATLKELTS LVKEVYPEAR KKGTHFNFAI VFTDVKRPGY RVKEIGSTMS GRKGTDDSMT LQSQKFQIGD YLDIAITPPN RAPPPSGRMR PY; Positive Samples: SW480; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle
Target Information
SAP18 is involved in histone acetylation, which plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 18 kDa Sin3-associated polypeptide; 2HOR0202; cell growth inhibiting protein 38; Cell growth-inhibiting gene 38 protein; epididymis secretory sperm binding protein; GIG38; histone deacetlyase complex subunit SAP18; Histone deacetylase complex subunit SAP18; SAP18; SAP18p; Sin3-associated polypeptide p18; sin3-associated polypeptide, 18 kDa; sin3-associated polypeptide, 18kDa; sin3-associated polypeptide, p18; Sin3A-associated protein, 18kDa; unnamed protein product
Gene Aliases: 2HOR0202; C530046K05Rik; D11Ertd539e; EMegR4; GIG38; SAP18; SAP18P; Sinbp1
UniProt ID: (Human) O00422, (Mouse) O55128
Entrez Gene ID: (Human) 10284, (Mouse) 20220, (Rat) 290284
regulation of alternative mRNA splicing, via spliceosome
regulation of transcription from RNA polymerase II promoter
mRNA processing
RNA splicing
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
negative regulation of mRNA splicing, via spliceosome
regulation of transcription, DNA-templated
chromatin modification
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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