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SAP97 Polyclonal Antibody

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View all (24) SAP97 antibodies

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SAP97 Polyclonal Antibody

Product Details

OSD00038W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Miscellaneous PubMed (Misc)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 2-50 of human SAP97 conjugated to blue carrier protein was used as the antigen
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in rat and mouse.

Specificity of this antibody: SAP97.

Target Information

This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene, but the full-length nature of some of the variants is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: discs large homolog 1, scribble cell polarity complex component; Disks large homolog 1; dJ1061C18.1.1; DKFZp761P0818; DKFZp781B0426; Drosophila discs-large tumor suppressor homologue (synapse associated protein); E-dlg/SAP97; Embryo-dlg/synapse-associated protein 97; hDlg; presynaptic protein SAP97; SAP-97; Synapse-associated protein 97; unnamed protein product

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Gene Aliases: B130052P05Rik; DLG1; DLGH1; E-dlg/SAP97; hdlg; mKIAA4187; SAP-97; SAP97

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UniProt ID: (Human) Q12959, (Rat) Q62696, (Mouse) Q811D0

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Entrez Gene ID: (Human) 1739, (Rat) 25252, (Mouse) 13383

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Function(s)
guanylate kinase activity phosphoprotein phosphatase activity protein binding cytoskeletal protein binding potassium channel regulator activity kinase binding protein kinase binding phosphatase binding ionotropic glutamate receptor binding ion channel binding cadherin binding binding, bridging L27 domain binding structural constituent of postsynaptic density protein C-terminus binding PDZ domain binding mitogen-activated protein kinase kinase binding protein complex scaffold scaffold/adaptor protein
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development branching involved in ureteric bud morphogenesis immunological synapse formation endothelial cell proliferation lens development in camera-type eye actin filament organization establishment or maintenance of cell polarity chemical synaptic transmission nervous system development protein localization cell proliferation positive regulation of cell proliferation regulation of cell shape actin filament polymerization peristalsis positive regulation of actin filament polymerization cortical actin cytoskeleton organization astral microtubule organization protein complex localization membrane raft organization regulation of myelination regulation of protein localization protein localization to synapse T cell proliferation T cell activation negative regulation of T cell proliferation regulation of membrane potential amyloid precursor protein metabolic process receptor clustering regulation of potassium ion transport positive regulation of potassium ion transport protein kinase B signaling cortical microtubule organization establishment or maintenance of epithelial cell apical/basal polarity GMP metabolic process GDP metabolic process reproductive structure development embryonic skeletal system morphogenesis tissue morphogenesis smooth muscle tissue development negative regulation of epithelial cell proliferation establishment of centrosome localization negative regulation of protein kinase B signaling hard palate development negative regulation of ERK1 and ERK2 cascade bicellular tight junction assembly protein localization to membrane protein localization to plasma membrane receptor localization to synapse cell-cell adhesion regulation of ventricular cardiac muscle cell action potential membrane repolarization during ventricular cardiac muscle cell action potential regulation of postsynaptic membrane neurotransmitter receptor levels maintenance of postsynaptic density structure neurotransmitter receptor localization to postsynaptic specialization membrane regulation of NIK/NF-kappaB signaling regulation of sodium ion transmembrane transport regulation of protein localization to synapse positive regulation of protein localization to plasma membrane regulation of potassium ion import negative regulation of p38MAPK cascade regulation of potassium ion export across plasma membrane protein localization to cell periphery negative regulation of G1/S transition of mitotic cell cycle T cell cytokine production cell adhesion single organismal cell-cell adhesion activation of protein kinase activity negative regulation of mitotic cell cycle nucleotide phosphorylation positive regulation of establishment of protein localization to plasma membrane positive regulation of multicellular organism growth positive regulation of developmental growth
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