|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||5 µg/ml|
|Western Blot (WB)||0.5-1 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||An 18 amino acid peptide from near the center of human SAPAP1.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human brain tissue lysate.
PA5-20531 can be used with blocking peptide PEP-0651.
SAP90/PSD-95-associated protein 1 (SAPAP1, also known as DLGAP1 or GKAP) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP1 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). SAPAP1 mRNA is targeted to cell bodies in a similar manner to SAPAP2 and -4, whereas SAPAP3 mRNA is detected mainly in cell bodies. SAPAP1 protein however, is targeted to the synapse and is not reliant on the synaptic localization of PSD-95 or the synaptic scaffolding molecule (S-SCAM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DAP-1; DAP-1 beta; DAP-1, DAP-1-ALPHA, DAP-1-BETA, GKAP, SAPAP1, hGKAP; discs large homolog associated protein 1; discs, large (Drosophila) homolog-associated protein 1; Disks large-associated protein 1; guanylate kinase associated protein; Guanylate kinase-associated protein; hGKAP; PSD-95 binding protein; PSD-95/SAP90 binding protein 1; PSD-95/SAP90-binding protein 1; rGKAP; SAP90/PSD-95 associated protein 1; SAP90/PSD-95-associated protein 1; SAPAP1
Gene Aliases: 4933422O14Rik; 9630002F18; AI845682; AI848168; BB075781; D17Bwg0511e; DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1; DLGAP1; DLGAP1A; DLGAP1B; GKAP; GKAP/SAPAP; GKAP/SAPAP1; GKPA/SAPAP; Kiaa4162; mKIAA4162; rGKAP; SAPAP1
Molecular Function: transmembrane receptor regulatory/adaptor protein
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