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Invitrogen
SAPK4 Monoclonal Antibody (R.618.4)
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Product Details
MA5-14994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
R.618.4
Immunogen
Synthetic peptide corresponding to residues around the carboxy terminus of p38d MAPK
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with other isoforms of p38 MAPK.
Target Information
MAPK13 (p38 delta) is a serine/threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase 13; MAP kinase p38 delta; MAPK 13; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; Stress-activated protein kinase 4
Gene Aliases: MAPK 13; MAPK-13; MAPK13; p38delta; PRKM13; SAPK4
UniProt ID: (Human) O15264
Entrez Gene ID: (Human) 5603, (Rat) 29513
MAPK cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
response to stress
response to osmotic stress
cell cycle
peptidyl-serine phosphorylation
positive regulation of interleukin-6 production
intracellular signal transduction
vascular endothelial growth factor receptor signaling pathway
positive regulation of inflammatory response
protein phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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