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Immunogen sequence: MLRLGAEYR LYPCPLFSVR FRKPLFGETG HTIMNLLADF RNYQYTLPVV QGLVVDMEVR KTSIKIPSNR YNEMMKAMNK SNEHVLAGGA CFNEKADSHL VCVQNDDGNY QTQAISIHNQ PRKVTGASFF VFSGALKSSS GYLAKSSIVE DGVMVQITAE NMDSLRQALR EMKDFTITCG KADAEEPQEH IHIQWVDDDK NVSKGVVSPI DGKSMETITN VKIFHGSEYK ANGKVIRWTE VFFLENDDQH NCLSDPADHS RLTEHVAKAF CLALCPHLKL LKEDGMTKLG LRVTLDSDQV GYQAGSNGQP LPSQYMNDLD SALVPVIHGG ACQLSEGPVV MELIFYILEN IV (1075-1425 aa encoded by B C032680)
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hSARA; MAD, mothers against decapentaplegic homolog interacting protein, receptor activation anchor; MADH-interacting protein; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; protein phosphatase 1, regulatory subunit 173; Receptor activation anchor; Smad anchor for receptor activation; Zinc finger FYVE domain-containing protein 9; zinc finger, FYVE domain containing 9
Gene Aliases: E030027L17; MADHIP; NSP; PPP1R173; SARA; SMADIP; ZFYVE9
UniProt ID: (Human) O95405