The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.
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Protein Aliases: HIV-1 Tat-interacting protein of 110kDa; hSART-3; MGC138188; mSART-3; p110 nuclear RNA-binding protein; SART-3; squamous cell carcinoma antigen recognized by T cells 3; Squamous cell carcinoma antigen recognized by T-cells 3; Tat-interacting protein of 110 kDa; Tip110; Tumor-rejection antigen SART3
Gene Aliases: AU045857; DSAP1; KIAA0156; mKIAA0156; P100; p110; p110(nrb); RP11-13G14; SART3; TIP110