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Product Details
21377-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SASS6 Fusion Protein Ag15917 (308-657 aa encoded by BC101026)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VECHEKEKH VNQLQTKVAV LEQEIKDKDQ LVLRTKEAFD TIQEQKVVLE ENGEKNQVQL GKLEATIKSL SAELLKANEI IKKLQGDLKT LMGKLKLKNT VTIQQEKLLA EKEEKLQKEQ KELQDVGQSL RIKEQEVCKL QEQLEATVKK LEESKQLLKN NEKLITWLNK ELNENQLVRK QDVLGPSTTP PAHSSSNTIR SGISPNLNVV DGRLTYPTCG IGYPVSSAFA FQNTFPHSIS AKNTSHPGSG TKVQFNLQFT KPNASLGDVQ SGATISMPCS TDKENGENVG LESKYLKKRE DSIPLRGLSQ NLFSNSDHQR DGTLGALHTS SKPTALPSAS SAYFPGQLPN S (308-657 aa encoded by BC101026)
Target Information
Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HsSAS-6; spindle assembly 6 homolog; Spindle assembly abnormal protein 6 homolog; Spindle assembly defective protein 6
Gene Aliases: MCPH14; SAS-6; SAS6; SASS6
UniProt ID: (Human) Q6UVJ0
Entrez Gene ID: (Human) 163786
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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