Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: PKTASQSLL VNLRAMQNFL QLPEAERDRI YQDERERSLN AASAMGPAPL ISTPPSRPPQ VKTATIATER NGKPENNTMN INASIYDEIQ QEMKRAKVSQ ALFAKVAATK SQGWLCELLR WKEDPSPENR TLWENLSMIR RFLSLPQPER DAIYEQESNA VHHHGDRPPH IIHVPAEQIQ QQQQQQQQQQ QQQQAPPPPQ PQQQPQTGPR LPPRQPTVAS PAESDEENRQ KTRPRTKISV EALGILQSFI QDVGLYPDEE AIQTLSAQLD LPKYTIIKFF QNQRYYLKHH GKLKDNSGLE VDVAEYKEEE LLKDLEESVQ DKNTNTLFSV KLEEELSVEG NTDINTDLKD (415-763 aa encoded by BC001744)
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling. SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support