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Invitrogen
SATB1 Polyclonal Antibody
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Product Details
PA5-96430
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 572-763 of human SATB1 (NP_0029621)
Conjugate
Form
Liquid
Concentration
0.54 mg/mL
Amount
54 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NAVHHHGDRP PHIIHVPAEQ IQQQQQQQQQ QQQQQQAPPP PQPQQQPQTG PRLPPRQPTV ASPAESDEEN RQKTRPRTKI SVEALGILQS FIQDVGLYPD EEAIQTLSAQ LDLPKYTIIK FFQNQRYYLK HHGKLKDNSG LEVDVAEYKE EELLKDLEES VQDKNTNTLF SVKLEEELSV EGNTDINTDL KD
Positive Samples: Jurkat, Mouse thymus, Rat thymus; Cellular Location: Nucleus, Nucleus matrix, PML body
Target Information
SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactiviation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence, and at nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 is also a transcriptonal repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner by binding to matrix attachment regions of DNA and inducing a local chromatin-loop remodeling. SATB1 modulates the genes that are essential in the maturatio of the immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide an unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein SATB1; putative; special AT-rich sequence binding protein 1; special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA); Special AT-rich sequence-binding protein 1; unnamed protein product
Gene Aliases: 2610306G12Rik; AW413156; DEFDA; DHDBV; KTZSL; SATB1
UniProt ID: (Human) Q01826, (Mouse) Q60611
Entrez Gene ID: (Human) 6304, (Mouse) 20230, (Rat) 316164
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
chromatin binding
helix-turn-helix transcription factor
DNA-binding transcription factor
Lambda repressor-like transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
epidermis development
chromatin modification
histone methylation
T cell activation
CD4-positive, alpha-beta T cell differentiation
CD8-positive, alpha-beta T cell differentiation
activated T cell proliferation
reflex
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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