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Proteintech
SATB2 Polyclonal Antibody
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Product Details
21307-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SATB2 Fusion Protein Ag15920 (228-369 aa encoded by BC098136)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KYKKIKVER VERENLSDYC VLGQRPMHLP NMNQLASLGK TNEQSPHSQI HHSTPIRNQV PALQPIMSPG LLSPQLSPQL VRQQIAMAHL INQQIAVSRL LAHQHPQAIN QQFLNHPPIP RAVKPEPTNS SVEVSPDIYQ QVR (228-369 aa encoded by BC098136)
Target Information
DNA-binding protein SATB2 binds to DNA at the nuclear matrix- or scaffold associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB2 is a transcription factor controlling nuclear gene expression by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. It also acts as a docking site for several chromatin remodeling enzymes by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. SATB2 is required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes - probably by modulating BCL11B expression. It is a repressor of Ctip2 and a regulatory determinant of corticocortical connections in the developing cerebral cortex. Mutations in the gene are associate with cleft palate isolated (CPI).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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