This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
PA1-734 detects secretory carrier membrane protein 2 (SCAMP 2) from mouse testes and AtT20 cell extract as well as Chinese hamster ovary (CHO) cell extract.
PA1-734 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~38 kDa protein representing SCAMP 2 from CHO cell extract.
PA1-734 immunizing peptide corresponds to amino acid residues 1-17 from human SCAMP 2. This sequence is completely conserved between human and mouse. PA1-734 immunizing peptide (Cat. # PEP-151) is available for use in neutralization and control experiments.
Secretory carrier membrane proteins (SCAMPs) are proteins that are components of post-Golgi membranes. These proteins are implicated to function in membrane trafficking. In fibroblasts, SCAMPs are concentrated in compartments that are involved in the recycling of cell surface receptors and endocytosis. In neurons, SCAMPs are associated with synaptic vesicles, secretion granules and transporter vesicles. SCAMPs are composed of four central transmembrane regions and a cytoplasmic tail. Of the five known SCAMPs, SCAMPs 1-3 contain cytoplasmic N-terminal regions with NPF repeats. NPF repeats are found to interact with EH domain proteins that function in budding of transport vesicles from the plasma membrane or the Golgi complex. SCAMPs 4 and 5 lack the N-terminal NPF repeats. SCAMPs 1-4 are all ubiquitously coexpressed while SCAMP 5 is only detectable in the brain. Studies show that SCAMP 5 is expressed late in development which is coincident with expansion of mature synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: scamp 2; Secretory carrier membrane protein 2; Secretory carrier-associated membrane protein 2; testis secretory sperm-binding protein Li 219p
Gene Aliases: AI875466; I79_023583; Sc2; SCAMP2
Molecular Function: transfer/carrier protein