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Invitrogen
SCAP Polyclonal Antibody
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FIGURE: 1 / 7
SCAP Antibody (PA5-35341) in ICC/IF
Immunocytochemistry analysis of SCAP in HeLa cells. Samples were incubated with SCAP polyclonal antibody (Product # PA5-35341) using a dilution of 1:100 for 2 h at room temperature followed by Alexa Fluor® 488 conjugated donkey anti-rabbit at a dilution of 1:1,000 for 1hr. Cells were fixed with 4% PFA (20 min) and permeabilized with Triton X-100 (0.2%, 30 min). Nuclei were counterstained with Hoechst 33342 (blue) (10 µg/mL, 5 min).
Product Details
PA5-35341
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 604-632 amino acids from the central region of human SCAP
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with bovine, mouse, porcine and rat based on sequence homology.
Target Information
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SCAP; scap {ECO:0000312|EMBL:AAI31853.1}; Sreb cleavage-activating protein; SREBP cleavage activating protein; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein; Sterol regulatory element-binding protein cleavage-activating protein
Gene Aliases: 9530044G19; KIAA0199; mKIAA0199; PSEC0227; SCAP
UniProt ID: (Human) Q12770, (Mouse) Q6GQT6, (Rat) A2RRU4
Entrez Gene ID: (Human) 22937, (Mouse) 235623, (Rat) 301024
response to hypoxia
lipid metabolic process
steroid metabolic process
cholesterol metabolic process
regulation of fatty acid metabolic process
response to insulin
SREBP signaling pathway
regulation of fatty acid biosynthetic process
regulation of cholesterol biosynthetic process
aging
negative regulation of cholesterol biosynthetic process
positive regulation of low-density lipoprotein particle receptor biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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