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SCARB1 Polyclonal Antibody
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FIGURE: 1 / 3
SCARB1 Antibody (600-401-EE0) in ICC/IF
Immunofluorescence Microscopy of SCARB1 antibody. Tissue: human spleen cells. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: SCARB1 antibody at 20 µg/mL for 1 hr at RT. Secondary antibody: Fluorescein rabbit secondary antibody at 1:10,000 for 45 min at RT. Localization: SCARB1is a membrane protein. Staining: SCARB1 as red fluorescent signal.
Product Details
600-401-EE0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-SCARB1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide near the N-terminus of human SCARB1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD36; CD36 and LIMPII analogous 1; CD36 antigen (collagen type I receptor thrombospondin receptor)-like 1 (scavanger receptor class B type 1); CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1; CD36 antigen-like 1; CLA-1; Collagen type I receptor, thrombospondin receptor-like 1; HDL QTL 1; scavanger receptor class B type 1; scavenger receptor b1; Scavenger receptor class B member 1; scavenger receptor class B type I; scavenger receptor class B type III; scavenger receptor class B1; SR-BI; SRB1; unnamed protein product
Gene Aliases: AI120173; CD36; CD36L1; CLA-1; CLA1; D5Ertd460e; HDLCQ6; Hdlq1; HDLQTL6; Hlb398; mSR-BI; SCARB1; SR-B1; SR-BI; SRB1; SRBI
UniProt ID: (Human) Q8WTV0, (Rat) P97943, (Mouse) Q61009
Entrez Gene ID: (Human) 949, (Rat) 25073, (Mouse) 20778
lipopolysaccharide binding
beta-amyloid binding
virus receptor activity
phosphatidylserine binding
lipopolysaccharide receptor activity
scavenger receptor activity
protein binding
1-phosphatidylinositol binding
high-density lipoprotein particle binding
lipid binding
low-density lipoprotein particle binding
apolipoprotein binding
apolipoprotein A-I binding
high-density lipoprotein particle receptor activity
lipid transporter activity
protein homodimerization activity
membrane trafficking regulatory protein
endothelial cell proliferation
cholesterol catabolic process
lipid transport
positive regulation of endothelial cell migration
positive regulation of nitric oxide mediated signal transduction
positive regulation of triglyceride biosynthetic process
positive regulation of cholesterol storage
regulation of phosphatidylcholine catabolic process
phospholipid transport
lipopolysaccharide transport
cholesterol transport
lipopolysaccharide-mediated signaling pathway
detection of lipopolysaccharide
cholesterol efflux
high-density lipoprotein particle remodeling
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
high-density lipoprotein particle clearance
vitamin transmembrane transport
wound healing
vasodilation
cholesterol homeostasis
blood vessel endothelial cell migration
recognition of apoptotic cell
reverse cholesterol transport
adhesion of symbiont to host
viral entry into host cell
regulation of phagocytosis
high density lipoprotein particle mediated signaling
triglyceride homeostasis
cholesterol import
intestinal lipid absorption
positive regulation of sphingolipid mediated signaling pathway
steroid biosynthetic process
androgen biosynthetic process
receptor-mediated endocytosis
phagocytosis, recognition
cell adhesion
positive regulation of nitric-oxide synthase activity
pattern recognition receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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