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Proteintech
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Immunogen sequence: LACCACCCW APRSDLKDRP ARDGATVSRM KLQVWGTLTS LGSTLPCRSL SSHKLPWVTV SHHDPEVPFN HSFIEPPSAG WATDDSFSSD PESGEADEVP AYCVPPQEGM VPVAQAGSSE ASLAAGAFPP PEDASTPFAI PRTSSLARAK RPSVSFAEGT KFAPQSRRSS GELSSPLRKP KRLSRGAQSG PEGREAEEST GPDEAEAPES FPAAASPGDS ATGHRRPPLG SRTVAEHVEA IEGSVQESSG PVTTIYMLAG KPRGSEGPVR SVFRHFGSFQ KGQAEAKVKR AIPKPPRQAL NRKKGSPGLA SGSVGQSPNS APKAGLPGAT GPMAVRPEEA VRGLGAGTES SRRAQEPVSG CGSPEQDPQK QAEEERQEEP EYENVVPISR PPEP (438-830 aa encoded by B C039735)
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described.
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