The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described.
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Protein Aliases: Acetyl LDL receptor; endothelial cells scavenger receptor; MGC47738; Scavenger receptor class F member 1; scavenger receptor class F, member 1; Scavenger receptor expressed by endothelial cells 1; Scavenger receptor expressed by endothelial cells 1 protein; SREC-I
Gene Aliases: AA986099; KIAA0149; mKIAA0149; SCARF1; SREC; SREC-I; SREC1