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Invitrogen
SCD Polyclonal Antibody
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FIGURE: 1 / 8
SCD Antibody (PA5-17331) in ICC/IF
Immunofluorescence analysis of SCD was performed using 70% confluent log phase 3T3-L1 undifferentiated and 3T3-L1 differentiated to adipocytes. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with SCD Polyclonal Antibody (Product # PA5-17331) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Recombinant Se... View More
Product Details
PA5-17331
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding M38 of human SCD1
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5., have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acyl-CoA desaturase; Acyl-CoA desaturase 1; asebia; Delta(9)-desaturase; Delta(9)-desaturase 1; Delta-9 desaturase; Delta-9 desaturase 1; delta-9-desaturase; Fatty acid desaturase; Fatty acid desaturase 1; HGNC:10571; hSCD1; OTTHUMP00000020280; predicted protein of HQ0998; PRO0998; PRO1933; Stearoyl-CoA desaturase; stearoyl-CoA desaturase (delta-9-desaturase); Stearoyl-CoA desaturase 1; stearoyl-CoA desaturase opposite strand
Gene Aliases: AA589638; ab; AI265570; FADS5; hSCD1; MSTP008; SCD; Scd-1; SCD1; SCDOS
UniProt ID: (Human) O00767, (Mouse) P13516
Entrez Gene ID: (Human) 6319, (Mouse) 20249
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
positive regulation of cholesterol esterification
cholesterol esterification
negative regulation of growth of symbiont in host
defense response to Gram-positive bacterium
white fat cell differentiation
brown fat cell differentiation
oxidation-reduction process
monounsaturated fatty acid biosynthetic process
unsaturated fatty acid biosynthetic process
long-chain fatty-acyl-CoA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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