A suggested positive control is rat brain tissue lysate.
PA5-20746 can be used with blocking peptide PEP-0860.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
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Protein Aliases: C-kit ligand; cloud gray; familial progressive hyperpigmentation 2; FPH2, KL-1, Kitl, MGF, SCF, SF, SHEP7, kit-ligand; grizzle-belly; Hematopoietic growth factor KL; Kit ligand; Mast cell growth factor; MGF; SCF; sKITLG; Soluble KIT ligand; Steel factor; steel factor/kit ligand; Stem cell factor; stem cell factor KL-1
Gene Aliases: blz; Clo; Con; contrasted; DCUA; DFNA69; FPH2; FPHH; Gb; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; Sl; SLF