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Invitrogen
SCF Polyclonal Antibody
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FIGURE: 1 / 1
SCF Antibody (PA5-23478) in WB
Western blot analysis of SCF in mouse liver lysate in the 1) absence and 2) presence of immunizing peptide. Samples were incubated in SCF polyclonal antibody (Product # PA5-23478) using a dilution of 4 µg/mL followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
Product Details
PA5-23478
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 121-158 of mouse kitl.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 100% homologous in mouse and 77% homologous in rat.
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; growth factor; H-SCF; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; polypeptide growth factor; SCF; SCF220; SCF248; steel factor; Stem cell factor; unnamed protein product
Gene Aliases: DCUA; DFNA69; FPH2; FPHH; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7; SLF; WS2F
UniProt ID: (Human) P21583
Entrez Gene ID: (Human) 4254
ovarian follicle development
neural crest cell migration
hematopoietic progenitor cell differentiation
myeloid leukocyte differentiation
positive regulation of leukocyte migration
positive regulation of myeloid leukocyte differentiation
developmental process involved in reproduction
apoptotic process
cell adhesion
Ras protein signal transduction
cell proliferation
positive regulation of cell proliferation
male gonad development
mast cell apoptotic process
negative regulation of mast cell apoptotic process
embryonic hemopoiesis
ectopic germ cell programmed cell death
T cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
positive regulation of melanocyte differentiation
positive regulation of Ras protein signal transduction
animal organ development
mast cell proliferation
positive regulation of mast cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
melanocyte migration
mast cell migration
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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