In sandwich ELISAs, less than 20% cross-reactivity with recombinant feline SCF is observed, less than 8% cross-reactivity with recombinant human SCF is observed, and less than 0.5% cross-reactivity with recombinant mouse SCF is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
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Protein Aliases: c-Kit ligand; familial progressive hyperpigmentation 2; FPH2; Kit ligand; kit-ligand; Kitl; KL-1; Mast cell growth factor; MGF; Processed kit ligand; SCF; SHEP7; sKITLG; Soluble KIT ligand; steel factor; Stem cell factor; stem cell factor, CSF
Gene Aliases: 710-712; CSF; KITLG; MGF
UniProt ID: (Dog) Q06220
Entrez Gene ID: (Dog) 403507