FIGURE: 1 / 3
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-terminal peptide; N-terminal peptide; Neuroendocrine protein 7B2; P SGNE1; Pituitary polypeptide; prohormone convertase chaperone; Secretogranin V; secretogranin V (7B2 protein); Secretogranin-5; Secretory granule endocrine protein I; secretory granule neuroendocrine protein 1; secretory granule neuroendocrine protein 1, 7B2 protein; Secretory granule neuroendocrine, protein 1 (7B2 protein); secretory granule, neuroendocrine protein 1 (7B2 protein)
Gene Aliases: 7B2; AI325031; P7B2; SCG5; Sgne-1; SGNE1; SgV
Molecular Function: chaperone